Introduction.A distinctive feature of the current stage of development of research activities in Ukraine is focus on harmonizing the functional interaction of generally accepted international requirements of quality management systems during conducting chemical safety assessment studies. An important place in this harmonization is taken by the implementation into practice of research organizations, where domestic regulatory requirements already exist (ISO/IEC 17025: General requirements for the competence of testing and calibration laboratories), principles of Good Laboratory Practice (OECD GLP).OECD GLP principles is a quality system of management controls for research laboratories and organizations to ensure the uniformity, consistency, reliability, reproducibility, quality, and integrity of various chemicals in non-clinical studies.ISO/IEC 17025 is a technical competence and management system standard developed specifically for testing and calibration laboratories. ISO/IEC 17025 is applied to a broad range of laboratories, including non-clinical laboratories.The same processes proceeded in different research departments of the same organization are often duplicated during conducting the study and preparation of documentation. Sometimes "duplication" leads to misunderstanding or inconsistency of interpretations of the same processes from the point of view of different quality systems. Therefore, providing harmonization and compatibility of various quality systems is an urgent task, the solution of which will allow to avoid ambiguity and reducing the quantity of documents aimed at providing and adherence of research processes in the laboratory, and will improve its quality.The purpose of the study was to introduce unified approaches of OECD GLP and ISO/IEC 17025 quality systems in safety assessment of chemicals.Materials and Methods. Expert-analytical review of OECD GLP and ISO/IEC 17025 regulatory documents has been conducted.Results and Conclusions. Quality system ISO/IEC 17025 is implemented in various research organizations which allow to obtain technically reasonable testing results. GLP accreditation is required in order to compare the quality of study results in order to mutually recognize data between research organizations of different countries. State enterprise «L.I. Medved's Research Centre of Preventive Toxicology, Food and Chemical Safety, Ministry of Health» (Research Centre) has implemented two quality systems: OECD GLP and National State Standard ISO/IEC 17025. Research Centre has a Quality Control Department which entities audits and supports quality of all procedures involved in studies in accordance with this two quality systems (fig. 1). Research Centre conducts non-clinical (toxicological) and field studies in accordance with the requirements of GLP (accreditation certificate of the Slovak National Accreditation Service (SNAS) № G-042) and physico-chemical, medico-biological, microbiological, ELISE tests are conducting in accordance with the require-Проблемні статті ABSTRACT. The article de...
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