Summary: This work presents a summary of current knowledge on the laboratory diagnosis of periodontitis. It focuses on the theoretical foundations and is supplemented with new knowledge. It subsequently describes specifically the laboratory diagnosis methods of periodontitis: the protein expression of inflammation, oral microbiology and molecular diagnostics. Periodontitis is a serious disease worldwide and its confirmed association with systemic diseases means its severity is increasing. Its laboratory diagnosis has the potential to rise to the level of clinical and diagnostic imaging. The transfer of diagnostic methods from laboratory to clinical use is increasingly used in the prevention and monitoring of the exacerbation and treatment of periodontal disease, as well as of its impact on systemic disease.
As the hardest and one of the most durable load bearing tissues of the body, enamel has attracted considerable interest from both material scientists and clinical practitioners due to its excellent mechanical properties. The aim of this investigation is to determine the influence of different loading conditions on the deformation behavior of human enamel using instrumented indentation and Berkovich indenter. The used samples were fresh intact human premolars, extracted due to orthodontic reasons. Hardness tests were performed with different loading regimes. To study the influence of loading rates tree different loading rates have been used with 10, 100 and 1000 mN/min. at maximum applied load of 200 mN. The indentation size effect (ISE) was studied using loads from 5 mN to 400 mN without holding time. The indents have been studied using atomoc force microscopy and scanning electron microscopy.
Omicron variant is more invasive against immunity, but it's not more invasive in any change in degree against masks, and indoor air; than previous variants. With its arrival, dentistry is facing another challenge. With a mission to protect both patients and healthcare workers, we are adapting to the current epidemiologic situation and anticipate the incoming change. This article presents an unpublished prospective setting for dental care in the new chapter of pandemics after Omicron variant. Introduced biosafety protocol has been clinically tested for 18 months in the field. Three fundamental pillars of this sustainable biosafety protocol are: (1) UVC air disinfection; (2) air saturation with certified virucidal oils through nebulizing diffusers; (3) telehealth solutions. As a method of evaluation pseudonymous on-line smart form was used. This biosafety protocol is not relying on persons` identification as uninfected; it is designed for environments where healthcare workers or patients are hypothetical asymptomatic carriers. Results from 115 patient feedbacks suggest that with this protocol in place, there was no observed or reported translation of infection from patient to another patient or from patient to doctor or nurse and vice versa, albeit nine of the patients have retrospectively admitted being probably infectious during their dental appointment. The key of this protocol is its clinical sustainability, as full-body protective suits don’t represent sustainable dental care as well as there is no acceptable risk of patients getting infected during dental procedures.
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