The use of Nd-YAG laser and PDL appears to be safe and effective measures in treatment of erythemato-telangiectatic rosacea. Both types of laser decrease the concentration of substance (P) in the skin. This effect is more pronounced with Nd-YAG laser.
To determine the efficiency of image analysis in immunohistochemical progesterone receptor (PgR) measurement, 94 primary breast carcinoma tissue samples were evaluated for PgR by biochemical dextran-coated charcoal assay (DCC) and an immunohistochemical method. Frozen sections immunostained for PgR with a monoclonal antibody (Abbott PgR-ICA, Chicago, IL) and the peroxidase-antiperoxidase technique were scored semiquantitatively histologic score by microscopy and quantitatively (percentage nuclear area immunopositivity [PNA] using the CAS 200 image analyzer (Cell Analysis Systems, Elmhurst, IL). There was a positive correlation between dextran-coated charcoal assay and both histologic score (r = 0.82) and PNA (r = 0.69). Selected cutoff points of 60 histologic score and 6.5% PNA based on sensitivity/specificity calculations yielded a predictive value of a negative test of 73% and 80%, respectively, and a positive predictive value of 100% for both; ranges of fmol/mg protein PgR correspond to ranges of histologic score and PNA. The use of an image analyzer to measure PNA in PgR-immunostained sections is a viable alternative to dextran-coated charcoal assay, especially when insufficient fresh tissue is available.
Introduction: chondroid lipoma is a rare, benign lipomatous tumor that may be mistaken histologically for a liposarcoma or chondrosarcoma. Herein, two cases of chondroid lipoma are reported in two Egyptian females aged 38 and 51 years and literature about this rare tumor briefly reviewed with discussion of diagnostic criteria that may help distinguish it from other tumors with overlapping histologic features. case series: the tumor was subcutaneous in both cases. One was located in the right knee area, the other in an infra-mammary location on the right side of the chest. Grossly, both neoplasms were encapsulated and exhibited a nodular, myxoid cut surface. Histologically, they consisted of an abundant myxoid and chondroid stroma interspersed by small round cells with eosinophilic or vacuolated cytoplasm, signet ring lipoblast-like cells, adipocytes and foci of mature adipose tissue. Immunohistochemically, diffuse reactivity of the neoplastic cells for vimentin and variable reactivity for s-100 protein were present in both cases. One case also showed focal immunoreactivity for cD68. the
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