Neodymium‐yttrium aluminum garnet laser versus pulsed dye laser in erythemato‐telangiectatic rosacea: comparison of clinical efficacy and effect on cutaneous substance (<scp>P</scp>) expression

Salem, Samar Abdallah Mohamed; Fattah, Nermeen S. A. Abdel; Tantawy, Samah M A; El-Badawy, N.; El-Aziz, Yasser A. Abd

doi:10.1111/jocd.12048

Cited by 30 publications

(23 citation statements)

References 18 publications

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“…Based on the finding that laser treatment in rosacea patients decreases the concentration of substance P in the skin, the authors concluded that substance P may play a central role in the pathophysiology of vascular changes. So far, this phenomenon has been demonstrated for both the PDL and the Nd:YAG laser .…”

Section: Light and Laser Devices For Vascular Changesmentioning

confidence: 85%

“…Interessante pathophysiologische Ansätze konnten in letzter Zeit von Lasertherapien abgeleitet und publiziert werden: Aufgrund der Beobachtung, dass nach Lasertherapie eine Reduktion der Substanz P in der papillären Dermis festzustellen ist, kann gefolgert werden, dass Substanz P eine zentrale Rolle in der Pathophysiologie der vaskulären Veränderungen spielen kann. Dieses Phänomen wurde bislang sowohl für den PDL als auch für den Nd:YAG-Laser nachgewiesen [ 14,15 ] . "Flushing"-Ereignisse beschrieben, hierzu gibt es einzelne Beobachtungen, jedoch keine standardisierten Studiendaten [ 11 ] .…”

Section: Farbstofflaser (Pdl)unclassified

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Physical modalities for the treatment of rosacea

Hofmann

Lehmann

2016

J Deutsche Derma Gesell

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SummaryRosacea is characterised by a wide variety of vascular changes. Apart from telangiectasia and erythema, often so-called flushing occurs. These vascular abnormalities can be targeted with specific light and laser devices. In addition to KTP laser, pulsed dye laser (PDL) and Nd:YAG laser, also intense pulsed light devices (IPLs) are used. The described therapeutic effects include the reduction of vascular abnormalities and even improvement of papulopustular changes. While the KTP laser shows very good results in telangiectasia, the dye laser and IPL devices are used preferably in erythema. The Nd:YAG laser is also a possibility for patients with telangiectasia and erythema. However, compared to the other laser and light devices the Nd:YAG laser carries the highest risk of unpredictable scarring. Phymatous changes are another clinical manifestation of rosacea, mostly affecting the nose (rhinophyma). Moderate and severe cases are commonly treated with ablation modalities. Traditional surgery is a treatment option, but is often associated with major intraoperative bleeding. Alternative methods include electrosurgery and dermabrasion, although both methods can cause scarring. Newer methods such as CO 2 laser ablation, possibly in combination with the erbium:YAG laser, are safe alternatives with a lower risk of complications.

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Section: Light and Laser Devices For Vascular Changesmentioning

confidence: 85%

Section: Farbstofflaser (Pdl)unclassified

Physical modalities for the treatment of rosacea

Hofmann

Lehmann

2016

J Deutsche Derma Gesell

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“…Recommendation Diffuse erythema and telangiectasia of rosacea can be effectively and safely reduced by the use of LPDL (595 nm) and KTP (532 nm) lasers, and IPLS (GRADE 1A) . Less evidence is available for millisecond and microsecond Nd:YAG (1064 nm) lasers (GRADE 1C) …”

Section: Treatment Of Different Vascular Lesionsmentioning

confidence: 99%

Guidelines of care for vascular lasers and intense pulse light sources from the European Society for Laser Dermatology

Adamič¹,

Pavlović

Rubin

et al. 2015

Acad Dermatol Venereol

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Aim Lasers and non-coherent intense pulse light sources (IPLS) are based on the principle of selective photothermolysis and can be used for the treatment of many vascular skin lesions. A variety of lasers has been developed for the treatment of congenital and acquired vascular lesions which incorporate these concepts into their design. Although laser and light sources are very popular due to their non-invasive nature, caution should be considered by practitioners and patients to avoid permanent side-effects. The aim of these guidelines is to give evidence-based recommendations for the use of lasers and IPLS in the treatment of vascular lesions. Results Lasers and IPLS are very useful and sometimes the only available method to treat various vascular lesions. It is of a paramount importance that the type of laser or IPLS and their specific parameters are adapted to the indication but also that the treating physician is familiar with the device to be used. The crucial issue in treating vascular lesions is to recognize the immediate end-point after laser treatment. This is the single most important factor to ensure both the efficacy of the treatment and avoidance of serious side-effects. Methods Conflicts of interestNone declared. Funding sourceNone.Since the publication of previous European Society of Laser Dermatology (ESLD) guidelines in 2007, there have been significant advances in the field of laser treatment of common vascular lesions.1 These guidelines have been updated by the Consensus Panel under the auspices of the ESLD. Methodology, search strategy and recommendation formulation are described in Appendix II. A brief overview of vascular lasersStandard vascular lasers include pulsed dye lasers (585 and 595 nm), and KTP-lasers (532 nm), followed by longer wavelength lasers such as alexandrite lasers (755 nm), diode lasers (800-900 nm) and millisecond Nd:YAG lasers (1064 nm). New developments include a non-uniform pulse sequence or a dual-wavelength modality (combined dual wavelength 595 and 1064 nm-pulsed dye and Nd:YAG laser) and microsecond Nd: YAG lasers. [2][3][4][5][6] Even fractional photothermolysis has begun to be used for selected vascular lesions. Lasers' and intense pulse light sources (IPLS) effects are based on the principle of selective photothermolysis. In general, they deliver a precisely graded aliquot of energy to a defined area of the skin in a reproducible, standardized manner that almost always involves addition or evacuation of heat. The greatestThe first two authors have contributed equally to the manuscript.

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Section: Licht‐ Und Lasertherapien Vaskulärer Veränderungenunclassified

Physikalische Methoden zur Behandlung der Rosazea

Hofmann

Lehmann

2016

J Deutsche Derma Gesell

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Die Rosazea ist durch vielfältige vaskuläre Veränderungen gekennzeichnet. Neben Teleangiektasien und Erythemen treten häufig auch sogenannte "Flushings" auf. Haupteinsatzgebiete von Licht- und Lasersystemen sind diese vaskulären Veränderungen, wie Erytheme und Teleangiektasien. Neben dem KTP-Laser, dem Farbstofflaser (PDL) und dem Nd:YAG-Laser kommen auch Blitzlampen (IPL) zum Einsatz. Neben der Rückbildung der vaskulären Komponente, ist auch eine Verbesserung der papulopustulösen Komponente beschrieben. Während der KTP-Laser sehr gute Ergebnisse bei Teleangiektasien zeigt, werden der Farbstofflaser und die Blitzlampen bevorzugt bei flächigen Erythemen eingesetzt. Der ND:YAG-Laser kann bei Teleangiektasien und Erythemen eingesetzt werden, birgt aber von allen Systemen das nicht einschätzbare Narbenbildungsrisiko in sich. Die Bildung von Phymen stellt eine klinische Ausprägung der Rosazea dar. Das am häufigsten vorkommende ist das Rhinophym. Bei moderaten und schweren Formen steht die Abtragung im Vordergrund. Die klassische chirurgische Abtragung stellt eine Möglichkeit zur Behandlung dar, häufig kommt es hierbei jedoch intraoperativ zu stärkeren Blutungen. Alternativmethode ist die Elektrochirurgie und die Dermabrasion, wobei bei beiden Methoden Narbenbildungen auftreten können. Neuere Methoden wie die CO -Laserabtragung, eventuell in Kombination mit der Erbium:YAG-Abtragung, stellen sichere und komplikationsärmere Varianten dar.

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Neodymium‐yttrium aluminum garnet laser versus pulsed dye laser in erythemato‐telangiectatic rosacea: comparison of clinical efficacy and effect on cutaneous substance (P) expression

Abstract: The use of Nd-YAG laser and PDL appears to be safe and effective measures in treatment of erythemato-telangiectatic rosacea. Both types of laser decrease the concentration of substance (P) in the skin. This effect is more pronounced with Nd-YAG laser.

Cited by 30 publications

References 18 publications

Physical modalities for the treatment of rosacea

Physical modalities for the treatment of rosacea

Guidelines of care for vascular lasers and intense pulse light sources from the European Society for Laser Dermatology

Physikalische Methoden zur Behandlung der Rosazea

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