Chondroid lipoma, a rare lipomatous tumor: A case series

Abstract

Introduction: chondroid lipoma is a rare, benign lipomatous tumor that may be mistaken histologically for a liposarcoma or chondrosarcoma. Herein, two cases of chondroid lipoma are reported in two Egyptian females aged 38 and 51 years and literature about this rare tumor briefly reviewed with discussion of diagnostic criteria that may help distinguish it from other tumors with overlapping histologic features. case series: the tumor was subcutaneous in both cases. One was located in the right knee area, the other in an infra-mammary location on the right side of the chest. Grossly, both neoplasms were encapsulated and exhibited a nodular, myxoid cut surface. Histologically, they consisted of an abundant myxoid and chondroid stroma interspersed by small round cells with eosinophilic or vacuolated cytoplasm, signet ring lipoblast-like cells, adipocytes and foci of mature adipose tissue. Immunohistochemically, diffuse reactivity of the neoplastic cells for vimentin and variable reactivity for s-100 protein were present in both cases. One case also showed focal immunoreactivity for cD68. the

Chondroid lipoma that may mimic malignancy: A case report

“…9 Chondroid lipomas are actually biphenotypic since they show lipoblastic differentiation and early cartilage features. 4 S-100 protein, vimentin, and CD-68 immunohistochemical staining are present on the tumor cells. In certain cases, focal keratin positivity has been discovered.…”

“…2 Chondrolipomas are uncommon benign fatty mesenchymal tumors that have proliferating mature adipocytes and varied amounts of mature cartilaginous tissue. 3,4 Generally speaking, chondroid lipomas are a rare form of lipomas that were first identified in 1976. 5 In 1993, Meis and Enzinger described it as a separate entity.…”

“…Numerous lipoma varieties have been documented, including osteolipoma, fibrolipoma, chondroid lipoma, angiolipoma, myolipoma, spindle cell lipoma, and chondroid lipoma 2 . Chondrolipomas are uncommon benign fatty mesenchymal tumors that have proliferating mature adipocytes and varied amounts of mature cartilaginous tissue 3,4 …”

“…Given their potential for growth, they have a higher likelihood of being incorrectly diagnosed as sarcomas. They are normally 4 cm, but can be as little as 1.5–11 cm 4,8 . There is no overt racial or geographical bias, although there is a preference for those who are approximately 40 years old (42.85 16.97; median, 41).…”

Chondroid lipoma associated with osteoclast-like multinucleated giant cells - a case report

“…The most common sites are in the proximal extremities and limb girdle . Rare cases were reported in breast , tongue , and chest wall . Clinically, patients usually present with a painless slowly growing mass .…”