The aim of the study was to investigate the prevalence of angina pectoris (AP) according to the standardized epidemiological questionnaire of Rose in the population of 25–45 years of Novosibirsk and to identify its association with some lipid and non-lipid risk factors for coronary heart disease (CHD). Material and methods. Cross-sectional survey of the population aged 25–45 in Novosibirsk was carried out. The study included 1439 people (656 men and 783 women). Within the framework of the complex survey program, the standardized epidemiological questionnaire of Rose (WHO, 1984) was used. Blood levels of total cholesterol (total C), triglycerides (TG), low and high density lipoprotein cholesterol (LDL–C, HDL–C) were determinate by biochemical methods. Results. For all lipid indicators, significant differences were found between men and women. The levels of total C, TG and LDL–C were significantly higher, and the level of HDL–C was lower in men, than in women. According to the Rose questionnaire, out of 1439 people included in the study, 12 patients (0.8%) had AP (75% women). In persons with AP, blood levels of TG were 1.8 times higher, and the levels of HDL–C in blood was 1.2 times lower compared to persons without AP. Univariate analysis of associations of AP with CHD risk factors showed that the chance of developing angina pectoris in the population of 25–45 years was significantly increased in individuals with high blood TG levels (OR 3,515, DI 1,106–11,168, p = 0.039) and low HDL–C (OR 1,203, DI 1,054–1,372, p = 0.006). A natural, although statistically not significant (OR 3,165, p=0,055, due to the small number of groups with AP) increasing in the chance of developing AP in hypertension was detected. Conclusion. In the young population of 25–45 years in Novosibirsk, elevated blood levels of TG, reduced levels of HDL–C, and hypertension were associated with AP, according to Rosecardiological questionnaire, which underlines the importance of conducting screening surveys of the young population to improve effective prevention and treatment of diseases.

Objective: The aim was to study the blood cytokine/chemokine profile of 25–44-year-old people with early ischemic heart disease (IHD) comorbid with abdominal obesity (AO). Methods: A cross-sectional medical examination of subjects in Novosibirsk, Russia, was conducted after random sampling of the above age group. A total of 1457 subjects, 804 females and 653 males, were analyzed. The epidemiological diagnosis of IHD was made in accordance with 17 validated and functional criteria, employing exercise ECG for confirmation. Simultaneous quantitative analyses of 41 cytokines/chemokines in blood serum were performed by a multiplex assay using the HCYTMAG-60K-PX41 panel (MILLIPLEX MAP) on a Luminex 20 MAGPIX flow cytometer, with additional ELISA testing. Results: Flt3 ligand, GM-CSF, and MCP-1 were significantly associated with the relative risk of early IHD. In the presence of AO, GM-CSF, MCP-1 and IL-4 also significantly correlated with the relative risk of early IHD. By univariate regression analysis, the relative risk of early IHD was associated with lowered blood concentrations of Flt3 ligand, whereas the relative risk of early IHD in the presence of AO was associated with lowered blood concentrations of GM-CSF. Employing multivariable regression analysis, only lower blood levels of Flt3 ligand were associated with a relative risk of early IHD, whereas the relative risk of early IHD in the presence of AO was limited to lower levels of IL-4. Conclusion: Findings related to Flt3 ligand, GM-CSF, and IL-4 are consistent with the international literature. Results from the present study are partly confirmative and partly hypothesis generating.

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Our approach combines the multiplier accelerator theory with the concept of efficient management of investment in socio-economic systems of various levels and thus it has enabled us to develop a matrix for diagnostics of investment processes by calculating investment efficiency (with the help of the investment multiplier) and the focus of the investment process (with the help of the investment accelerator). Upon these results we have mapped municipalities according to their levels of investment development and proposed a differentiated approach to managerial decision-making.These findings can be used to study investment attractiveness on the municipal level and to develop guidelines for assessment of investment attractiveness and for managerial decision-making to enhance investment efficiency.

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Aim. To study the associations of electrophysiological signs of metabolic disorders with lipid and non-lipid risk factors in the urban 25–44-year-old population.Methods. A population survey (random sample) of Novosibirsk residents aged 25–44 years (656 men, 783 women) was conducted. The concentrations of total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol, and triglycerides were determined. Systolic / diastolic blood pressure, body mass index, presence of arterial hypertension, and smoking status were evaluated. The following electrocardiographic markers of metabolic disturbances were analyzed: baseline non-ischemic ST elevation depression >0.5 mm, baseline ST elevation >0.5 mm, and T-wave changes (flattening, amplitude reduction, inversion).Results. ST segment depression was detected in 4.2% of subjects (5.8% women, 2.4% men (p = 0.001)). ST segment elevation was detected in 28.5% of subjects (17.5% women, 41.6% men (p<0.001)). T-wave changes were detected in 18.9% of subjects (14.2% women, 24.5% men (p<0.001)). It was noted that men with elevated LDL-C levels and hypertension were more likely to have ST segment depression (1.4 and 1.9 times, respectively) than men without these abnormalities. In the general population, people with elevated LDL-C levels were 1.2 times more likely to have ST segment depression. Among men with ST segment elevation the concentration of LDL-C in the blood was 1.06 times higher than in men without ST segment elevation. People with a higher body mass index were 1.15 and 1.3 times more likely to have a T-wave change (in the general and female population, respectively). In the general population with T-wave changes, waist circumference and systolic blood pressure level were 1.02 and 1.02 times higher, respectively.Conclusion. ST segment elevation and depression, and T-wave changes are associated with lipid and non-lipid risk factors for ischemic heart disease. The data obtained indicate a potentiating effect of metabolic disorders in the body on the development of risk factors for ischemic heart disease and metabolic cardiomyopathy.

Abstract The aim of this study was to investigate the prevalence of early ischemic heart disease (IHD) in accordance with standardized epidemiological criteria in the 25–44-year age group in Novosibirsk (Russia) and to identify associations with some risk factors and socioeconomic factors.Materials and methods. A cross-sectional populational medical examination was conducted on a random sample of the 25–44-year age group in Novosibirsk. A total of 1457 people were analyzed (653 males and 804 females). Epidemiological IHD diagnosis was made according to validated epidemiological (cardiological Rose questionnaire) and functional criteria (recording of an ECG interpreted via the Minnesota Code). The “definite IHD” diagnosis was made in the presence of the following criteria: a history of large-focal myocardial infarction (ECG), tension angina pectoris (Rose questionnaire), ischemic changes on ECG without left ventricular hypertrophy (ECG). Further, the diagnosis of "definite IHD" was confirmed by conducting an ECG test with physical activity. The evaluated IHD modifiable risk factors were cigarette smoking, elevated body mass index, elevated waist circumference, the presence of arterial hypertension, low physical activity, and elevated blood levels of low-density lipoprotein cholesterol, non–high-density lipoprotein cholesterol, and triglycerides. Socioeconomic factors were assessed too: marital status, occupation type, education, health self-rating, and economic status.Results. The prevalence of definite IHD in the study population was found to be 3.36% (49 subjects): 2.8% (18 subjects) among males and 3.9% (31 subjects) among females. All quantitative data on IHD risk factors were higher in males than in females. The prevalence of IHD risk factors (except for elevated waist circumference) was higher among males than females. The prevalence of IHD risk factors (except for cigarette smoking) was not different between IHD and no-IHD groups in the study population. Smoker prevalence was 1.66-fold higher (p = 0.031) in the no-IHD group than in the IHD group. Multivariate logistic regression analysis uncovered an inverse association of cigarette smoking (independently of age, sex, and other risk factors) with the relative risk of early IHD in the study population. Furthermore, in males, the relative risk of definite IHD (regardless of age) directly correlated with heavy manual labor (odds ratio [OR] = 3.495, confidence interval [CI] 1.306–9.353, р = 0.013) and unfavorable marital status (divorced or widowed; OR = 4.976, CI 0.944–26.228, р = 0.058). Meanwhile, these two factors inversely correlated with cigarette smoking (OR = 0.202, CI 0.060–0.672, р = 0.009).Conclusion. In males aged 25–44 years in Novosibirsk, the relative risk of early IHD is directly associated with heavy manual labor or unfavorable marital status, and these factors are inversely associated with smoking. This correlation needs further research.The medical-examination–based screening was performed within the framework of a government-funded research topic in State Assignment No. АААА-А17-117112850280-2. The biochemical and functional analyses were financially supported by a Russian Federation President grant for leading scientific schools, No. НШ-2595.2020.7.

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