The global prevalence of diabetes mellitus (diabetes) reached 6.6% (285 million patients) in 2010 and is expected to be 7.8% (438 million patients) in 2030. Among patients with coronary heart disease, the incidence of diabetes is higher, than in the population, and the incidence of cardiovascular disease is higher in patients with diabetes. The Cardiovascular Health Study, which included individuals 65 years of age and older, found that the incidence of clinical or subclinical cardiovascular disease was 70% in individuals with normal glucose levels, 77% in people with advanced glucose, and 86% - for people with first-time diagnosed or verified diabetes mellitus
According to the results of measurement of height, weight and calculation of body mass index in 1059 inhabitants of a large industrial center (Kharkiv) over the age of 45 years, are actively traded in the policlinics, was characterized the frequency of abdominal obesity (criteria: waist and waist / hips ratio) with taking into account sex characteristics. It was found that 83 % of screening participants had an abdominal obesity, including 56 % — expressed abdominal obesity. Excessive accumulation of adipose tissue in the waist as compared with those in hips occurred in 47 % of patients. It was proved the necessity increase the activity and effectiveness of primary prevention activities in relation to the abdominal type of obesity not only in obese and overweight, but also in patients with a normal body mass index
* Дослідження виконано в межах наукової тематики Харківської медичної академії післядипломної освіти МОЗ України «Порушення здоров'я сім'ї у кризових станах різного ґенезу. Причини, механізми розвитку, клінічні прояви і система психодіагностики, психокорекції, психопрофілактики» (номер державної реєстрації 0112U000972) та «Медико-психологічні наслідки соціального стресу та інформаційно-психологічної війни (макро-, мікросоціальні чинники дезадаптації, механізми формування, система психодіагностики, психокорекції, психопрофілактики)» (номер державної реєстрації 0117U000371). Установою, що фінансує дослідження, є МОЗ України. Автори гарантують повну відповідальність за все, що опубліковано в статті. Автори гарантують відсутність конфлікту інтересів і власної фінансової зацікавленості при виконанні роботи та написанні статті. Рукопис надійшов до редакції 25.03.2019.
The study is devoted to the issue of expanding the diagnostic algorithm for the growth hormone deficiency (GHD) in children on the platform of combining the methods of clinical medicine, medical epidemiology and medical geography. The Geographic information systems (GIS) methods were used in the course of clinical observation and GHD prevalence analysis in children in various parts of the Odessa region in the period from 2012 to 2020 (t = 8 years) with the constant inclusion of new patients. In total, 92 children were included in the study; the ratio of boys to girls is 3:1. The prevalence of GHD (t = 8 years) was 19.7 cases per 100,000 children. There were no regional features of the clinical presentation of GHD in children of the Odessa region. In most cases, the disease was idiopathic, congenital, isolated, with a predominance of the peak GH level in 2 stimulation tests in the range of 7-10 ng / ml. The greatest prevalence of DHD (35,8 per 100 000 children) was found in the Foreststeppe zone of the Odessa region , which has a number of territorial geophysical features, according to local GIS data. These include hydrogeological anomalies, altered magnetic and gravitational fields, pinpoint increases in the content of uranium, radon, radium, mercury, lead and deficiencies in the content of Zn, Co, Mo. In the central part of the Forest-steppe zone (Ananyevsky district), a steady 4,7 times excess of the average regional prevalence the GHD in children was noted (93,4 per 100 000 children). Local GIS data and materials of the epidemiological study permit to define this territory as a GHD-associated zone. The possibility of using the GIS method to improve the diagnosis of GHD based on increasing diagnostic alertness and improving medical management was established.
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