The detection of stress-induced premature aging with the aim of correcting damaging adaptive effects seems to be actual today. The article discusses the use of the DHEAS / cortisol index as a screening marker for accelerating the rate of biological aging in people exposed to stress.
Technological capabilities make it possible to increase the diagnostic efficiency of quantitative immunochemiluminescent studies but require expanding the glossary of the clinical and laboratory consultation, taking into account metrological approaches to quality assurance. The variants of quantitative assessment of the “clinical uncertainty of assessing the patient’s condition based on a laboratory test”, formed taking into account the models of analytical quality requirements, are proposed. The clinical significance of the introduction of metrological approaches to ensuring and expressing accuracy in the practice of quantitative immunochemiluminescent studies in order to reduce risks and improve the safety of medical activities is demonstrated.
In this paper, the metabolic syndrome (MS) is considered as a manifestation of an excessive adaptive response of the body, which underlies premature aging. It is relevant to search for new early markers of MS formation in LPA in the context of modern ideas about the role of universal mechanisms of adaptation and stress-induced premature aging in its pathogenesis. The data obtained by the authors allow us to consider the relative androgen deficiency as a predictor of the formation of MS in LPA. The results of the study demonstrate that the levels of triiodothyronine and DHEAS serve as early markers of the formation of MS, while the testosterone/estradiol ratio is a universal laboratory indicator of accelerated aging of the body and MS.
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