However, the reason for this may be that almost all the lesions were distal and the distance to be covered by the outgrowing axons was therefore not great. Secondary suture should be undertaken as soon as the primary wound has healed and the tissues are free from induration. Primary suture proved an unreliable operation, although some good results were seen. There are important technical reasons why secondary suture is more satisfactory. If, as is often the case, there has been intraneural damage it is much easier to recognize it some weeks after the injury than at the time, because it reveals itself as a palpable and, on section, visible zone of intraneural fibrosis. The resection can be planned accordingly. Furthermore, the epineurium becomes thickened after the injury, and after a few weeks is an ideal structure for holding fine sutures. Most of the repairs reported were secondary.Where there is associated damage to tendons it is best to repair them at the time of injury and simply to approximate the severed nerves. When mobilization of the digits is well advanced secondary suture of the nerves is performed without disturbance of the tendons, which, at the wrist, lie on a deeper plane, and continued movement of the fingers has no adverse effect on the nerve suture. REPERENCESBrooks. D. M (1Q55).

The effects of eighteen substituted benzoic acids on the rate of oxygen consumption have been studied in rats. 2: 3-Dihydroxybenzoic acid, phthalic acid and 6-methylsalicylic acid were, at the doses used, inactive; m-and p-hydroxybenzoic acid, 2:4-, 2:5-, 2:6-, 3:4-, and 3: 5-dihydroxybenzoic acid, o-aminobenzoic acid, salicyluric acid, salicylamide and 5-aminosalicylic acid decreased the rate of oxygen consumption. Only salicylic acid and o-, m-andp-cresotic acid (3-, 4-and 5-methylsalicylic acid respectively) increased the rate of oxygen consumption. Molar potency ratios of the cresotic acids as metabolic stimulants relative to salicylic acid were determined; o-cresotic acid was the most powerful with a ratio of 2.61, m, and p-cresotic acid had values of 1.78 and 1.89 respectively. Two possible explanations of the higher potencies of the cresotic acids were considered. No difference in the primary action of the drug was established by determining the effect on rate of oxygen consumption of a mixture of o-cresotic and salicylic acids. An alternative possibility was that the rates of detoxication and excretion of the cresotic acids differed among themselves and from salicylic acid. No such differences were found.It is well established that sodium salicylate, in moderate dosage, increases the rate of oxygen consumption of experimental animals (Singer, 1901 ;Reid, 1957) and man (Barbour and Devenis, 1919; Cochran, 1952).Meade (1954) found that only salicylic acid, among all the mono-and di-hydroxybenzoic acids, increased the rate of oxygen consumption of rats; m-hydroxybenzoic acid was a depressant and the other acids were inactive. Hall, Tomich, and Woollett (1954) investigated a number of antirheumatic compounds and other substances chemically related to salicylic acid. They found that only salicylic acid and acetylsalicylic acid increased the rate of oxygen consumption of rats or mice; 2:5-and 2: 6-dihydroxybenzoic acid, mand p-hydroxybenzoic acid and salicylamide were inactive.The present work compares eighteen substituted benzoic acids with respect to their ability to stimulate oxygen consumption; the relative potencies of the active compounds are compared and commented upon.The rat was chosen as the most practical experimental animal, the smallest in which changes in oxygen consumption can be easily detected over 1 hr. periods. METHODSOxygen consumption was measured with a closedcircuit manometric method described by Cameron (1958).In the first experiments Wistar albino rats weighing 230 to 290 g. were used. The animals were paired for sex and weight, and in each run one animal received the test solution while the other received an identical volume of normal saline. The drugs were administered by intraperitoneal injection as solutions of the sodium salts at pH 7 to 9; the doses administered were the highest that could be tolerated. Dose/Response Experiments. -The compounds used in these experiments were salicylic acid and o-, m-, and p-cresotic acid (3-, 4-, and 5-methylsalicylic acid respectively). Wistar ...

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