Aspirin and Diabetes Mellitus

Abstract

However, the reason for this may be that almost all the lesions were distal and the distance to be covered by the outgrowing axons was therefore not great. Secondary suture should be undertaken as soon as the primary wound has healed and the tissues are free from induration. Primary suture proved an unreliable operation, although some good results were seen. There are important technical reasons why secondary suture is more satisfactory. If, as is often the case, there has been intraneural damage it is much easier to recognize it some weeks after the injury than at the time, because it reveals itself as a palpable and, on section, visible zone of intraneural fibrosis. The resection can be planned accordingly. Furthermore, the epineurium becomes thickened after the injury, and after a few weeks is an ideal structure for holding fine sutures. Most of the repairs reported were secondary.Where there is associated damage to tendons it is best to repair them at the time of injury and simply to approximate the severed nerves. When mobilization of the digits is well advanced secondary suture of the nerves is performed without disturbance of the tendons, which, at the wrist, lie on a deeper plane, and continued movement of the fingers has no adverse effect on the nerve suture. REPERENCESBrooks. D. M (1Q55).

Therapeutic Methods Against Insulin Resistance

“…Earlier reports indicated that high doses of sodium salicylate dramatically reduced glycosuria in diabetes patients [16,63,64,114]. Several years later, other authors [114][115][116] confirmed that high doses (500 mg or more) of aspirin by 2 -3 weeks can reduce glycosuria and blood glucose levels in diabetic patients, and in addition to reduced insulin requirements.…”

“…On the contrary, clinical evidences suggest that, based on the anti-inflammatory, anti-platelet and anti-thrombotic effects of aspirin [18,[63][64][65][66][67][68][69], the hypothalamic and pancreatic ischemia can improve by recanalization (increase blood flow to the existing arteries). While an omental transposition (pedicled graft) on the pancreas may be useful against pancreatic ischemia, due to revascularization (formation of new blood vessels), and besides this, provides stem cells from the omentum [14,70,71].…”

“…Other hormonal antagonists such as cortisol, growth hormone, glucagon and catecholamines are each capable of producing states of insulin resistance. Therefore, anti-inflammatory drugs [64,65] can reverse or improve this dysfunction of receptor caused by the lipotoxicity of the adipokines [5,69,94,104], as shown in Figure 3. Then, the chronic lipotoxicity of the adipokines in the insulin receptors of obese adults can cause the formation of free radicals, oxidate stress, degeneration and cell death in many cells of the body [4][5][6]108].…”

Impact of diabetes on alpha-crystallins and other heat shock proteins in the eye

“…It has been shown that aspirin and other nonsteroidal antiinflammatories such as paracetamol and ibuprofen are able to prevent or delay the onset of cataracts during diabetes [48]. Nonsteroidal antiinflammatories can lower fasting glucose levels of diabetics and nondiabetics and diminish glycosuria in diabetic patients and alloxan diabetic rats, which could, in turn, decrease glycation of crystallins and, subsequently, related cataract onset [49,50]. Furthermore, mutation to alpha-crystallin mimicking some specific posttranslational modifications can lead to cataractogenesis.…”

Aspirin Inhibits Serine Phosphorylation of Insulin Receptor Substrate 1 in Tumor Necrosis Factor-treated Cells through Targeting Multiple Serine Kinases

“…It has been known for more than a century that salicylates are able to reduce fasting blood glucose in diabetic patients (1)(2)(3). The cellular and molecular mechanism of the hypoglycemic activity of aspirin has not been well elucidated.…”