In this paper, a noise-resistant image encryption scheme is proposed. We have used a cubic-logistic map, Discrete Wavelet Transform (DWT), and bit-plane extraction method to encrypt the medical images at the bit-level rather than pixel-level. The proposed work is divided into three sections; In the first and the last section, the image is encrypted in the spatial domain. While the middle section of the proposed algorithm is devoted to the frequency domain encryption in which DWT is incorporated. As the frequency domain encryption section is a sandwich between the two spatial domain encryption sections, we called it a "sandwich encryption." The proposed algorithm is lossless because it can decrypt the exact pixel values of an image. Along with this, we have also gauge the proposed scheme's performance using statistical analysis such as entropy, correlation, and contrast. The entropy values of the cipher images generated from the proposed encryption scheme are more remarkable than 7.99, while correlation values are very close to zero. Furthermore, the number of pixel change rate (NPCR) and unified average change intensity (UACI) for the proposed encryption scheme is higher than 99.4% and 33, respectively. We have also tested the proposed algorithm by performing attacks such as cropping and noise attacks on enciphered images, and we found that the proposed algorithm can decrypt the plaintext image with little loss of information, but the content of the original image is visible.INDEX TERMS Discrete Wavelet Transform (DWT), Chaotic map, Medical images, Bit-plane decomposition, Security analysis of medical images.

The advancement in wireless communication has encouraged the process of data transferring through the Internet. The process of data sharing via the Internet is prone to several attacks. The sensitive information can be protected from hackers with the help of a process called Encryption. Owing to the increase in cyberattacks, encryption has become a vital component of modern-day communication. In this article, an image encryption algorithm is suggested using dynamic substitution and chaotic systems. The suggested scheme is based upon the chaotic logistic map, chaotic sine maps and the dynamical substitution boxes (S-boxes). In the proposed scheme, the S-box selection is according to the generated sequence by deploying the chaotic sine map. To evaluate the robustness and security of the proposed encryption scheme, different security analysis like correlation analysis, information entropy, energy, histogram investigation, and mean square error are performed. The keyspace and entropy values of the enciphered images generated through the proposed encryption scheme are over 2 278 and 7.99 respectively. Moreover, the correlation values are closer to zero after comparison with the other existing schemes. The unified average change intensity (UACI) and the number of pixel change rate (NPCR) for the suggested scheme are greater than 33, 99.50% respectively. The simulation outcomes and the balancing with state-of-the-art algorithms justify the security and efficiency of the suggested scheme.

No abstract

Background: Cyclosporine A (CsA) is an exceptional immunosuppressant used for the treatment of immune disorders. Niosomal vesicles are promising drug carriers that are formed by self-association of nonionic surfactants and cholesterol in an aqueous phase. The objective of the study was to formulate combined nonionic surfactant based vesicles and to evaluate their in vitro characterization, release studies and in vivo studies. Materials and Methods: Five niosomal formulations (F 7 to F 11) were prepared using the thin film hydration method. The molar ratio of cholesterol and non-ionic surfactant taken was 1:1. In formulation F 10 , the combination of surfactants Span 20 and Brij 35 was used. The niosomes were characterized by zeta sizer and SEM for particle size analysis, in vitro drug release and stability studies. The pharmacokinetic studies were conducted on healthy albino rabbits. Results: The size of niosome was found in the range of 427.1 nm to 972.3 nm. SEM image of optimized formulations F 10 exhibit the spherical nature of niosomal vesicles. DSC thermograms of niosomal formulations exhibited a broadened endothermic peak. The stability study exhibited that all formulations are stable and negligible change of vesicle size and entrapment was observed with time. The percentage drug release was significantly higher as compared to CsA plain dispersion for all niosomal formulations at pH 1.2 and 7.4. The release kinetic behavior showed that all preparations were best described by zero order and can release active ingredient in a sustained manner. The pharmacokinetic data showed the test formulation (F10) possessed greater bioavailability as compared to the reference formulation (CsA aqueous dispersion). Conclusion: The formulation F 10 demonstrated a comparatively more delayed rate of release with enhanced dissolution as compared to a single surfactant scheme. The F 10 formulation can be a remarkable nanotechnology for prolonged delivery of CsA orally with improved dissolution profile and bioavailability.

No abstract

VANET is an application and subclass of MANETs, a quickly maturing, promising, and emerging technology these days. VANETs establish communication among vehicles (V2V) and roadside infrastructure (V2I). As vehicles move with high speed, hence environment and topology change with time. There is no optimum routing protocol which ensures full-pledge on-time delivery of data to destination nodes, and an absolutely optimum scheme design for flawless packet exchange is still a challenging task. In VANETs, accurate and on-time delivery of fundamental safety alert messages (FSAMs) is highly important to withstand against maliciously inserted security threats affectively. In this paper, we have presented a new security-aware routing technique called VANSec. The presented scheme is more immune and resistive against different kinds of attacks and thwarts malicious node penetration attempts to the entire network. It is basically based on trust management approach. The aim of the scheme is to identify malicious data and false nodes. The simulation results of VANSec are compared with already existing techniques called trust and LT in terms of trust computation error (TCE), end-to-end delay (EED), average link duration (ALD), and normalized routing overhead (NRO). In terms of TCE, VANSec is 11.6% and 7.3% efficient than LT and trust, respectively, while from EED comparison we found VANSec to be 57.6% more efficient than trust and 5.2% more efficient than LT. Similarly, in terms of ALD, VANSec provides 29.7% and 7.8% more stable link duration than trust and LT do, respectively, and in terms of NRO, VANSec protocol has 27.5% and 14% lesser load than that of trust and LT, respectively.

This paper presents the synthesis and design of the multi-mode dual-band bandstop filter (MM-DBBSF). A highly selective multi-mode dual-band bandstop response is obtained using a quarter wavelength coupled line structure. It has been shown that by increasing the coupled line's order, the selectivity and the transmission zeros are increased in the desired stopband. Moreover, a step impedance resonator (SIR) is used between two coupled lines to achieve more transmission poles for better out of band selectivity. The paper show a detailed theoretical synthesis of the coupled line and SIR structure. In order to validate the theoretical model, ideal and microstrip topologies are designed and simulated. Furthermore, a high-frequency substrate is used to fabricate four prototypes. The simulated and measured results show good concurrence.

Purpose: To formulate niosomes of cyclosporine A using nonionic surfactants, and to use the attenuated total reflectance/Fourier transform infrared (ATR-FTIR) technique to explore solid/liquid interfacial phenomena as well as compatibility between active drug and pharmaceutical excipients. Methods: Niosomes of cyclosporine A were prepared using the thin-film hydration method. Cholesterol and non-ionic surfactants, including polyethylene glycol sorbitan monostearate (Tween 60) and sorbitan monostearate (Span 60), were used as excipients. The ATR-FTIR spectra of all the ingredients, their physical mixtures, and niosomal formulations were studied. The niosomes were characterized for size, polydispersivity index (PDI), zeta potential, and entrapment efficiency. Results: Six niosomal formulations (F1 -F6) were successfully developed. Niosomal formulation F2 prepared at the ratio of 6:4 surfactant to cholesterol, presented the highest entrapment efficiency of 77.28 %. The ATR-FTIR spectra of niosomal formulations did not show incompatibility. The size of the selected formulation (F2) was 1049 nm while its SEM image displayed a spherical nature of the niosomes. Conclusion: The results show that cyclosporine A can be entrapped in niosomes using non-ionic surfactants and cholesterol. Furthermore, there is no significant interaction between the ingredients of niosomes and cyclosporine A.This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest