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Plant Rumput Mutiara (Hedyotiscorymbosa (L.) Lamk) is one of the family species of Rubiaceae which is used as a traditional medicine that is effective in healing boils, acne, anti-inflammatory, and anticancer. Research methods include maceration, fractionation, purification, class test and bioactivity test with Kirby-Bauer diffusion method using E.coli bacteria. The results of this research are pure isolates with white crystal needle shape with melting point 137-138°C. Pure isolates were analyzed using FTIR, and by the IR spectrum which showed the absorption band at wave numbers 3435.22 cm-1 indicated the presence of –OH, CH3 and-CH2- aliphatic groups (2956.87 cm-1; 2935.66 cm-1; 2893.22 cm-1; and 2866.22 cm-1), C = C (1641.42 cm-1), -CH3 and-CH2- bending (1462.04 cm-1 and 1377.17 cm- 1), CO (1056.99 cm-1), and = CH (964.41 cm-1). Based on the result, it showed that the isolate was steroid group which has low antibacterial activity againts E.coli with inhibition power of 10 mm.

Usnic acid is chemical compound commonly found in lichen. These derivatives compounds both from the synthesis and from the isolation of various lichens have been studied as antibacterial, antifungal, antiparasitic, antiviral, and anticancer. Usnat acid derivative with not hydroxyl group on carbon C-3 was isolated from lichen usnea sp. taken from the Sinjaiselatan described in this paper. Its bioactivity against Arthemia Salina Leach. LC50 value of 19.49 μg/mL.

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Abstract-This study aimed to develop a module practicum of chemistry analysis integrated-based on green chemistry to improve environmental the attitude of students which is valid and efficient. The four-step of the plump model adopted was used in the development of the module. These stages are the initial assessment phase, the planning stage, the stage of realisation/construction and implementation phase. The first three steps are used to develop and validate the module, while the last step is used to measure the effectiveness of the module. The module contains three main part, namely introduction, learning activity and bibliography. The introduction to the module containing a general explanation, the general objectives of learning, and the specific goals of learning. Learning activities section contains descriptions of learning contents, summaries, test, answer key, and feedback. A validation test was submitted to two green chemistry experts, two pedagogic experts, and one environment expert. The effectiveness of the module has been carried out by giving learning achievement test and observe environment attitude of a group of 25 students. The test of learning achievement cover attitude of the environment. Results of this study show that the module has a valid category with 3.2 scores. The average learning achievement and environment attitude of the students increase from score 6.45 to 18.29 of score total 22 and from 40.66 % to 65.97 %, respectively. Those are related to the effectiveness of the module.

The development of natural ingredients use for conventional medicine is now in high requirement due to the traditional drugs are reasonably undemanding to be achieved. Annonaceae is one plant family which is usually utilized as medical plants in Indonesia and many other countries. One species of the family which is regularly used as customary medicine is A. muricata Linn which is well-known as soursop that comes from Caribbean, Central America, and South America. Along with the technological advancement, compounds and efficacy of soursop plant becomes popular. Annona muricata Linn. or soursop belongs to the Annonaceae family that is traditionally used to treat various diseases, such as cancer, diarrhea, convulsive, fungal and itching. The purpose of this study was to isolate and purify secondary metabolites of ethyl acetate fraction of the soursop stem bark. Research methods include extraction (maceration), fractionation and BLST test against Artemia salina. The structure of the 17.18-dihydroxy montecristin compound was determined by IR, 1H and 13C-NMR spectra HMBC and COSY. The compound had an activity to the tumor cell of murine leukemia cells P-388 with the IC50 value of 34.05 mg/mL respectively. This study found that the compound of 17.18-dihydroxy montecristin have been isolated from the stem bark of A. Muricata L. which has potential as an anticancer with the IC50 of 34.05 µg/mL.

Plant Belajang Susu (Scindapsus pictus Hassk.) is a species of the genus Scindapsus including Araceae family that has long been used by Mambi traditional communities as anticancer. Plant that include genus Scindapsus are generally used as ornamental plants, and there are also used as medicinal plants because they contain active compounds and can be antiinflammatory, analgesic, antioxidant and anti-tumor. Methods used included of extraction or maceration, phytochemical test, fractionation and bioactivity test extract with Brine Shrimp Lethality by using Artemia salina. From the results of the phytochemical test it is known that methanol extract of Belajang Susu contain alkaloid and steroid, while toxicity method Brine shrimp lethality test, showed that activity extract methanol Belajang Susu with each LC50 value 1,1365 μg mL−1.