Phytochemical Test and Toxicity Test for Methanol Extract of Belajang Susu (Scindapsus pictus Hassk.)

Abstract

Plant Belajang Susu (Scindapsus pictus Hassk.) is a species of the genus Scindapsus including Araceae family that has long been used by Mambi traditional communities as anticancer. Plant that include genus Scindapsus are generally used as ornamental plants, and there are also used as medicinal plants because they contain active compounds and can be antiinflammatory, analgesic, antioxidant and anti-tumor. Methods used included of extraction or maceration, phytochemical test, fractionation and bioactivity test extract with Brine Shrimp Lethality by using Artemia salina. From the results of the phytochemical test it is known that methanol extract of Belajang Susu contain alkaloid and steroid, while toxicity method Brine shrimp lethality test, showed that activity extract methanol Belajang Susu with each LC50 value 1,1365 μg mL−1.

Fractions 14 and 36K of Metabolite Extract Streptomyces hygroscopicus subsp. Hygroscopicus Have Antimalarial Activities Against Plasmodium berghei in vitro

“…MCF-7 cell line has been used for examining the cytotoxic effect of antimalarial drugs in several previous studies. [27][28][29][30][31][32] Cancer cells are more susceptible to toxic drugs than the majority of normal cells because they actively divide at considerably greater rates, and this is related to mitotic spindles and DNA replication in cancer cells. 25,48 Other study showed relatively uniform toxicity results of cell lines and normal cell lines.…”

“…26 Other studies have been using breast cancer cell MCF-7 in antimalarial toxicity test. [27][28][29][30][31][32] In addition, cancer cell lines and normal cell lines exhibited relatively uniform toxicity results. 24 So, the purpose of this study is to evaluate the antimalarial effectiveness of fractions 14 and 36K against Plasmodium berghei and their toxicity on MCF-7 cells as a novel prospective antimalarial drug candidate in vitro.…”