No abstract

No abstract

No abstract

No abstract

No abstract

No abstract

No abstract

35 Plants are vital for the wellbeing of humankind in a variety of ways. Some plant extracts contain 36 antimicrobial properties that can treat different pathogens. Most of the world's population relies 37 on medicinal plants and natural products for their primary health care needs. Therefore, there is a 38 growing interest in natural products, medicinal plants, and traditional medicine along with a 39 desire to design and develop novel plant-based pharmaceuticals. These plant-based 40 pharmaceuticals may address the concerns of reduced efficacy of synthetic antibiotics due to the 41 emergence of drug-resistant pathogens. In this regard, some plant extracts from black pepper 42 (Piper nigrum) with antimicrobial properties, including piperine, have the potential to be used as 43 natural dietary supplements together with modern therapeutic approaches. This review highlights 44 possible applications of piperine as the active compound in the fields of rational drug design and 45 discovery, pharmaceutical chemistry, and biomedicine. We discuss different extraction methods 46 and pharmacological effects of the analyzed substance to pave the way for further research 47 strategies and perspectives towards the development of novel herbal products for better 48 healthcare solutions.49 50