Honey and cancer: A mechanistic review

Waheed, Marwa; Hussain, Muhammad Bilal; Javed, Ahsan; Mushtaq, Zarina; Hassan, Sadia; Shariati, Mohammad Ali; Khan, Muhammad Usman; Majeed, Majid; Nigam, Manisha; Mishra, Abhay Prakash; Heydari, Mojtaba

doi:10.1016/j.clnu.2018.12.019

Cited by 86 publications

(85 citation statements)

References 54 publications

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“…It is reported to exert antibacterial [ 4 , 5 , 6 , 7 ], antifungal [ 8 ], and antiviral activity [ 9 , 10 , 11 ]. In addition, it exhibits anti-inflammatory and wound-healing action [ 12 ], as well as anticancer properties [ 13 , 14 , 15 ]. Its antioxidant properties vary in tandem with its botanical origin [ 16 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Biological Properties of Bee Bread Collected from Apiaries Located across Greece

et al. 2021

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Bee bread is the only fermented product of the beehive. It constitutes the main source of proteins, lipids, vitamins, and macro- and microelements in honeybee nutrition and it exerts antioxidant and antimicrobial properties, though research on these aspects has been limited so far. In this study 18 samples of Greek bee bread, two of which were monofloral, were collected during different seasons from diverse locations such as Crete and Mount Athos and were tested for their bioactivity. Samples were analyzed for their antibacterial properties, antioxidant activity, total phenolic content (TPC), and total flavonoid content (TFC). The antimicrobial activity of each sample was tested against Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Salmonella typhimurium. Our data demonstrate that all samples exert inhibitory and most of them bactericidal activity against at least two pathogens. Furthermore, all samples exert significant antioxidant activity, where the monofloral Castanea Sativa sample demonstrated superior antioxidant activity. Nevertheless, the antioxidant and antimicrobial activity were not strongly correlated. Furthermore, machine learning methods demonstrated that the palynological composition of the samples is a good predictor of their TPC and ABTS activity. This is the first study that focuses on the biological properties of Greek bee bread and demonstrates that bee bread can be considered a functional food and a possible source of novel antimicrobial compounds.

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Section: Introductionmentioning

confidence: 99%

Biological Properties of Bee Bread Collected from Apiaries Located across Greece

et al. 2021

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“…Honey contains more than 180 substances, and the main compounds are sugars, water, and minerals [ 3 ]. Honey also contains small amounts of phenolic compounds, vitamins, organic acids, enzymes, and amino acids [ 4 ]. Glucose and fructose are the main sugars in honey and represent more than 70% of the composition of honey [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

The Influence of Chemical Contaminants on the Physicochemical Properties of Unifloral and Multifloral Honey

Scripcă

Amariei

2021

Foods

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The aim of this study was to evaluate and compare the effect of antibiotic and pesticide residues on the physicochemical properties of unifloral and multifloral honey. The mineral elements content of honey was analyzed and correlated with antibiotic and pesticide residues, and a positive correlation was found between manganese and neonicotinoids. Potassium was found to be the most abundant mineral compound. Correlations were found between mineral content, color, and the content of antibiotic and pesticide residues of honey. In meadow honey, residues of antibiotics and pesticides were undetectable. In some of the other types of honey, the maximum residue limits regulated by European legislation were exceeded. Endosulfan residue was found in mint and rapeseed, honey with 0.42 and 5.14 ng/g, respectively. Neonicotinoids were found in 27% of the analyzed honey samples. Chloramphenicol was identified only in rapeseed honey, with concentrations ranging from 0.2 ng/g to 0.8 ng/g. Nitrofurans were found in 14%, and nitroimidazoles were found in 6% of the analyzed samples. According to EU legislation that is in force, the use of antibiotics in beekeeping is not allowed. The MRLs for neonicotinoids are 50 ng/g, and for coumaphos, the maximum limit is 100 ng/g. For the other pesticide residues, the maximum limit is 10 ng/g. The results of statistical analysis obtained using principal component analysis (PCA) showed a major difference in the levels of contamination of raspberry and meadow honey and the other types of honey.

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“…It is well-known that inflammatory cells control the cancer microenvironment, while inflammation plays a crucial role in cancer progression [ 74 , 75 ]. It is also reported in a mechanistic review that the mechanisms for anticancer activity of honey are antioxidant, anti-inflammatory, apoptotic, immunomodulatory, TNF inhibiting, antiproliferative and provide estrogenic effects [ 76 ]. However, this study was not specific to SBH, and although there are some studies that have reported the anticancer activity of SBH, though the mechanisms of its activity are still not completely clear.…”

Section: Stingless Bee Honeymentioning

confidence: 99%

“…Propolis (a resin-like substance, colloquially known as bee glue) is a substance that bees produce by mixing salivary secretions, beeswax, pollen and other resins harvested from botanical sources, mainly trees [ 83 ]. Additionally, geopropolis is a type of less malleable propolis only produced by some stingless bee species (for example, Melipona fasciculata and Melipona quadrifasciata anthidioides ) and it is mixed with additional material (soil or clay) [ 76 ]. The benefits of SBP have been known for centuries and well-studied, similarly to SBH, and has shown four main medicinal properties; antioxidant, anti-inflammatory, anticancer and antimicrobial activities ( Table 2 ).…”

Section: Stingless Bee Propolis (Sbp)mentioning

confidence: 99%

Antioxidant-Based Medicinal Properties of Stingless Bee Products: Recent Progress and Future Directions

et al. 2020

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Stingless bees are a type of honey producers that commonly live in tropical countries. Their use for honey is being abandoned due to its limited production. However, the recent improvements in stingless bee honey production, particularly in South East Asia, have brought stingless bee products back into the picture. Although there are many stingless bee species that produce a wide spread of products, known since old eras in traditional medicine, the modern medical community is still missing more investigational studies on stingless bee products. Whereas comprehensive studies in the current era attest to the biological and medicinal properties of honeybee (Apis mellifera) products, the properties of stingless bee products are less known. This review highlights for the first time the medicinal benefits of stingless bee products (honey, propolis, pollen and cerumen), recent investigations and promising future directions. This review emphasizes the potential antioxidant properties of these products that in turn play a vital role in preventing and treating diseases associated with oxidative stress, microbial infections and inflammatory disorders. Summarizing all these data and insights in one manuscript may increase the commercial value of stingless bee products as a food ingredient. This review will also highlight the utility of stingless bee products in the context of medicinal and therapeutic properties, some of which are yet to be discovered.

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Honey and cancer: A mechanistic review

Cited by 86 publications

References 54 publications

Biological Properties of Bee Bread Collected from Apiaries Located across Greece

Biological Properties of Bee Bread Collected from Apiaries Located across Greece

The Influence of Chemical Contaminants on the Physicochemical Properties of Unifloral and Multifloral Honey

Antioxidant-Based Medicinal Properties of Stingless Bee Products: Recent Progress and Future Directions

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