Hirschsprung's disease (HD), or congenital megacolon, is a disease characterized by the absence of ganglion cells in the myenteric (Auerbach's) and submucosal (Meissner's) plexuses of the intestine, causing maximum obstruction in neonates. The purpose of this study was to investigate patient characteristics, clinical presentation, investigations, surgical treatment, and outcome. This study is a retrospective study of HD cases. Data obtained from medical records at the institution. Of the 109 with a positive rectal biopsy diagnosis, 91 were patients with this disease. There were more cases in boys than girls with a ratio of 1.37: 1. The patients were grouped into 4 age groups: neonates 29 cases (26.61%); infants/toddlers/young children 55 cases (50.46%); children over 5 years16 cases (14.69%); and teenagers 9 cases (8.24%). The neonates generally presented with abdominal distension, green vomiting, and a history of delayed meconium release, while the toddler, child, and adolescent groups experienced constipation and abdominal distension. Furthermore, from 37 patients (33.94%) that got barium enema examination, the most common transition zone was observed in the rectosigmoid (17 patients, or 45.9%). In addition, The Duhamel procedure was the most frequent pull-through procedure found in our cohort which was performed in 40 patients (36.70%). In conclusion, HD is mostly found in male infants/toddlers/young children with abdominal distention and chronic constipation as common symptoms. The barium enema shows the rectosigmoid as the most common transition zone, while the Duhamel pull-through procedure is the primary definitive operative action performed.
INTRODUCTION: Anal traumas, such as blunt and penetrating injuries to the perineum, can disrupt the anal sphincter and cause considerable morbidity. Non-invasive anal trauma therapies have been widely developed, including growth factors administered as platelet-rich plasma (PRP) and stromal vascular fraction (SVFs) containing adipose[1]derived stem cells (ASCs) and limited growth factor. This study aimed to assess PRP and SVF effects on capillary histopathology in the anal trauma Wistar rat model. MATERIALS AND METHODS: This experimental study used a rat model. Rats were divided into three groups: Group A (n=12) was treated with PRP and SVFs; Group B (n=12) was treated with normal saline (placebo); Group C (n=4) was sacrificed on day 0 to obtain baseline capillary counts. Groups A and B were further divided into three subgroups, sacrificed on days 1, 7, and 14 post-treatment. RESULTS: Capillary counts significantly showed higher density between Groups A and B (p=0.037, analysis of variance). On day 7, there was a significant difference between Groups A and B (p=0.001). CONCLUSION: Mean capillary density significantly improved in anal trauma treated with a combination of PRP and SVFs compared to control. Our findings support the use of PRP and SVFs to aid recovery of patients with anal trauma.
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