Introduction: Diabetic foot ulcers (DFU) is a major social issue in terms of treatment cost. DFU has a high risk of infection with morbidity and an increased risk of lower-extremity amputations. Currently, there are no satisfactory treatments for DFU. This motivates a search for methods that can stimulate the acceleration of wound healing; one of these methods is the use of hyperbaric oxygen therapy (HBOT). This study attempts to prove the ability of HBOT to accelerate the healing process of DFU by increasing levels of both serum Interleukin 6 (IL-6) and Vascular Endothelial Growth Factor (VEFG), assessed by the perfusion, extent, depth, infection and sensation (PEDIS) score. Methods: Twenty DFU patients were divided into two groups. The control group underwent a holistic DFU treatment without HBOT and was tested twice for serum IL-6 and VEGF levels, 1 day apart. The HBOT group underwent a holistic DFU treatment with HBOT and was also tested twice for serum IL-6 and VEGF levels: one day before HBOT and 2 h after the first day of HBOT. Results: The changes in serum IL-6 and VEGF levels were greater in patients with HBOT than in control patients (p = 0.025 and p = 0.004). As for PEDIS score assessment, the HBOT group had significantly lower PEDIS scores than the control group (p < 0.001). Conclusion: HBOT can help accelerate the wound healing process, which was proven by increased serum IL-6 and VEGF levels and a lower PEDIS score. Highlights:
Introduction: Limb injury is a major health concern that imposes a direct danger to both life and limb viability. At Kandou Hospital Manado, hyperbaric oxygen (HBO) therapy has been performed as an adjunctive treatment for crush injury although no study has yet directly compared outcomes of HBO versus conventional therapy. Documentation of the association between HBO therapy and the healing process of crush injury is necessary to reduce the gaps in the literature and to establish an evidence-based clinical use of HBO therapy. Methods: In this study, we assessed the changes in the vascular endothelial growth factor (VEGF) serum levels and VEGF mRNA expression as biomarkers of wound healing using ELISA and qRT-PC at four different measurement times: at baseline, after receiving initial treatment (debridement and limb-salvage surgeries), 2 h after the first session HBOT, and after a full 10 HBOT sessions. A randomized controlled trial (RCT) was used to enroll patients subjected to crush injury who were admitted to the Surgical Emergency Department (ER) of Kandou Hospital Manado, Indonesia. Results: VEGF serum levels increased significantly in patients suffering from crush injury who received HBO therapy versus the control group. The increased VEGF serum is expected to result in an acceleration time of wound healing and a reduction in amputation rate. Conclusion: There was a significant difference between crush injury patients who received conservative therapy versus those receiving HBO therapies; thus, there was an increased likelihood of an accelerated wound healing and a reduction in the risk of amputation. Highlights
Head injury is a medical injury that is directly or indirectly in the head which effects the injury to the scalp, skull fracture, tear on the lining of the brain, damage of the brain tissue, and neurological disorders. Head injury considered minor if the degree of total GCS is 14 – 15. Purpose: The research is aimed to get the CT Scan appearance on the minor head injury based on sex, age, and the causes on Surgery Department og BLU RSUP Prof. Dr. R. D. Kandou Manado period 2012 – 2013. Method: This research used descriptive retrospective methode by collecting data in Medical Record department of RSUP Prof. Dr. R. D. Kandou Manado. Conclusion: Among 105 cases of minor head injury, only 89 cases that met the criteria of inclusion study. Patients with minor head injury were mostly men, as many as 76% with largest age group range >15 – 20 years by 26%. The causes of minor head injury that most found was traffict accident as many as 73%. There were 11% minor head injury patients who had normal picture of CT Scan result, whreas the most abnormal CT Scan appearance was ICH as many as 34%. Keywords : The Skull CT Scan appearance, Minor head injury Abstrak: Cedera kepala adalah cedera mekanik yang secara langsung atau tidak langsung mengenai kepala yang mengakibatkan Luka di kulit kepala, fraktur tulang tengkorak, robekan selaput otak, dan kerusakan jaringan otak itu sendiri, serta mengakibatkan gangguan neurologis. Cedera kepala dikatakan ringan bila derajat GCS total adalah 14-15. Tujuan: Penelitian ini bertujuan untuk mengetahui gambaran CT Scan kepala pada penderita cedera kepala ringan berdasarkan jenis kelamin, umur dan penyebab di IGD Bedah BLU RSUP Prof. Dr. R. D. Kandou Manado periode 2012 - 2013. Metode: Metode yang digunakan adalah metode deskriptif retrospektif, dengan mengumpulkan data di bagian Rekam Medik RSUP Prof. Dr. R. D. Kandou Manado. Simpulan: Dari 105 kasus cedera kepala ringan, hanya 89 kasus yang memenuhi kriteria inklusi penelitian. Pasien cedera kepala ringan yang paling banyak adalah laki – laki sebanyak 76 % dengan kelompok umur terbanyak >15 – 20 tahun sebanyak 26 %. Penyebab cedera kepala ringan yang paling sering adalah kecelakaan lalu lintas sebanyak 73%. Sebanyak 11% pasien cedera kepala ringan memiliki hasil CT Scan dengan gambaran yang normal, sedangkan gambaran CT Scan abnormal yang paling banyak adalah ICH sebanyak 34%. Kata kunci: Gambaran CT Scan Kepala, Cedera Kepala Ringan
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