Disruptive Technology is one of the backbones of Indutry4.0, In this era the company's large size is no longer a guarantee. Speed ​​in adapting to the development and behavior of consumers is the main key. Therefore, companies must be sensitive and do self-introspection so they can detect their position in the midst of the development of science and technology in order to maintain their existence and have the opportunity to dominate the market. PT Supermall   Karawaci, which is engaged in the retail business, needs to adapt and understand this rapid technological development, so for this business sector requires interaction with customers. The current system is good, but in some procedures that make customer service less than optimal and will be better if there is an effort so that customer loyalty can increase and of course the company's profit will increase. Therefore, the writers make this problem as a foundation in research and application development (E-CRM), the writers use the method of observation, elicitation, SWOT, Unified Modeling Language (UML), prototype and black box as methods of data collection, analysis, design and testing. For design, programming, web server and database, the writer uses Adobe XD applications, Android Studio, PHP, XAMPP and Microsoft SQL Server.

Future healthcare systems and organizations demand huge computational resources, and the ability for the applications to interact and communicate with each other, within and across organizational boundaries. This chapter aims to explore state-of-the-art of the healthcare landscape and presents an analysis of networked healthcare systems with a focus on networking traffic and architectures. To this end, the relevant technologies including networked healthcare architectures and performance studies, Health Level 7 (HL7), big data, and cloud computing, are reviewed. Subsequently, a study of healthcare systems, applications and traffic over local, metro, and wide area networks is presented using multi-hospital cross-continent scenarios. The network architectures for these systems are described. A detailed study to explore quality of service (QoS) performance for these healthcare systems with a range of applications, system sizes, and network sizes is presented. Conclusions are drawn regarding future healthcare systems and internet designs along with directions for future research.

Future healthcare systems and organizations demand huge computational resources, and the ability for the applications to interact and communicate with each other, within and across organizational boundaries. This chapter aims to explore state-of-the-art of the healthcare landscape and presents an analysis of networked healthcare systems with a focus on networking traffic and architectures. To this end, the relevant technologies including networked healthcare architectures and performance studies, Health Level 7 (HL7), big data, and cloud computing, are reviewed. Subsequently, a study of healthcare systems, applications and traffic over local, metro, and wide area networks is presented using multi-hospital cross-continent scenarios. The network architectures for these systems are described. A detailed study to explore quality of service (QoS) performance for these healthcare systems with a range of applications, system sizes, and network sizes is presented. Conclusions are drawn regarding future healthcare systems and internet designs along with directions for future research.

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BACKGROUND: One of the main causes of blindness for diabetic patients is cataract. The molecular mechanisms that may be involved in diabetic cataract include polyol pathway flux, increased formation of advanced glycation end products, osmotic stress, and elevated oxidative stress. AIM: The aim of the study was to explore the anticataract activity of the ethanol extract from pericarp of Garcinia mangostana Linn (GML) in Goat eye lens. METHODS: Goat eye lenses separated to five groups were incubated in M199 medium, added by penicillin of 100 U/ml and streptomycin of 0.1 mg/ml in a 37°C incubator with 95% O2 and 5% CO2 for 120 h. Group I served as the normal control. Group II (toxic control) the lenses were added by 30 mM glucose. The lenses in Groups III, IV, and V nurtured in M199 medium with 30 mM of glucose added by 100, 500, and 1000 μg/ml of GML pericarp extract. Carboxymethyllysine (CML), GRP78, DDIT3, active caspase 3, and MDA levels were measured by enzyme-linked immunosorbent assay assays. Comparisons of biochemical parameters were conducted using one-way ANOVA with post hoc Tukey test. RESULTS: The administration of glucose 30 mM increased MDA, CML, DDIT3, and GRP78, and active caspase 3 levels in Group II. Groups III, IV, and V which treated with GML pericarp extract decreased MDA, CML, GRP78, and DDIT3, and active caspase 3 levels inside the lens. On lens capsule, the CML and GRP78 levels increased. CONCLUSION: Ethanol extract of GML pericarp potentially showed antioxidant, anti-glycation, DDIT3 inhibitor, and anti-apoptotic activity in Goat cultured lenses.