Antibiotic resistance and its rapid spread among pathogenic bacterial isolates are regarded as major public health issues around the world. The study aims to detect pyogenic bacteria in pus samples and assess their antibiotic susceptibilities to various antibiotics commonly employed in chemotherapeutic interventions. This is a retrospective study in which 297 pus samples were obtained from patients in the year 2018 to 2020 for aerobic culture and sensitivity testing. In total, 32% (95) of the samples yielded positive results, whereas, 68% (202) yielded negative results. The most commonly occurring pathogen was E. coli (65) followed by Pseudomonas spp. ( 14), Staphylococcus aureus (9), Klebsiella spp. (4) and Acinetobacter spp. (3). Patients aged 51 and up were the ones who were largely afflicted by the pus infection. Males were shown to be more susceptible to infection than females. Amikacin, Ceftazidime, Meropenem, Cefotaxime, Netilmicin, Mecillinam, and Fosfomycin were the most susceptible drugs for Klebsiella spp., followed by Meropenem for E. coli, Cloxacillin, Doxacillin, Cefotaxime, and Amoxiclave for S. aureus. However, Pefloxacin and Amoxiclav were both effective against Pseudomonas spp., while Levofloxacin, Ciprofloxacin, Doxacillin, Tazobactam+Piperacillin, Imipenem, Netilmicin, and Trimethoprim were effective against Acinetobacter spp. The antibiotic, Ampicillin was found to be resistant to all of the microorganisms tested. In general, most of the isolates were found to be resistant to the majority of the antibiotics. As a result of our research, clinicians will be able to make better decisions when selecting appropriate antibiotics, which aid in patient care and judicious usage, preventing the development of drug resistance in those who are already susceptible.
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