Functional hemodynamic responses are the composite results of underlying variations in cerebral oxygen consumption and the dilation of arterial vessels after neuronal activity. The development of biophysically based models of the cerebral vasculature allows the separation of the neuro-metabolic and neuro-vascular influences on measurable hemodynamic signals such as functional magnetic resonance imaging or optical imaging. We describe a multicompartment model of the vascular and oxygen transport dynamics associated with stimulus-driven neuronal activation. Our model offers several unique features compared with previous formulations such as the ability to estimate baseline blood flow, volume, and oxygen consumption from functional data. In addition, we introduce a capillary compliance model, arterial and venous oxygen permeability, and model the dynamics of extravascular tissue oxygenation. We apply this model to multimodal optical spectroscopic and laser speckle imaging of the rat somato-sensory cortex during nine conditions of whisker stimulation. By fitting the model using a psuedo-Bayesian framework to incorporate multimodal observations, we estimate baseline blood flow to be 94 (615) mL/100 g min and baseline oxygen consumption to be 6.7 (61.3) mL O 2 /100 g min. We calculate parametric, linear increases in arterial dilation (R 2 = 0.96) and CMRO 2 (R 2 = 0.87) responses over the nine conditions. Other parameters estimated by the model include vascular transit time and volume reserve, oxygen content, saturation, diffusivity rate constants, and partial pressure of oxygen in the vascular compartments and in the extravascular tissue. Finally, we compare this model to earlier work and find that the multicompartment model more accurately describes the observed oxygenation changes when compared with a single compartment version. Blood Flow & Metabolism (2007) 27, 1262-1279 doi:10.1038/sj.jcbfm.9600435; published online 3 January 2007 Keywords: CBF and oxidative metabolism; human and experimental studies; hemodynamics; optical imaging and spectroscopy; NIRS (near-infrared spectroscopy); MRI hemodynamics Journal of Cerebral IntroductionThe ability of magnetic resonance imaging or optical techniques to measure functional changes in blood volume, flow, or hemoglobin oxygenation has led to important advances in modern neuroscience and has contributed to our current understanding of the functional anatomy of the brain (reviewed by Nair, 2005). However, the interpretation of these hemodynamic-derived measurements is complicated by the fact that these changes are the result of the competing effects of the increased metabolic demand for oxygen to support glycolysis and the increased supply of oxygen offered by the elevated regional perfusion of blood via the dilation of feeding arteries (reviewed by Buxton et al, 2004;Mintun et al, 2001). Imaging methods, such as the blood oxygen level-dependent signal in functional magnetic resonance imaging (fMRI) or optical imaging, measure these composite changes and are less reveal...

Stimulus evoked changes in cerebral blood flow, volume, and oxygenation arise from vascular responses to underlying neuronally mediated changes in vascular tone and cerebral oxygen metabolism. There is increasing evidence that the magnitude and temporal characteristics of these evoked hemodynamic changes are additionally influenced by the local properties of the vasculature including the levels of baseline cerebral blood flow, volume, and blood oxygenation. In this work, we utilize a physiologically motivated vascular model to describe the temporal characteristics of evoked hemodynamic responses and their expected relationships to the structural and biomechanical properties of the underlying vasculature. We use this model in a temporal curve-fitting analysis of the high-temporal resolution functional MRI data to estimate the underlying cerebral vascular and metabolic responses in the brain. We present evidence for the feasibility of our model-based analysis to estimate transient changes in the cerebral metabolic rate of oxygen (CMRO 2 ) in the human motor cortex from combined pulsed arterial spin labeling (ASL) and blood oxygen level dependent (BOLD) MRI. We examine both the numerical characteristics of this model and present experimental evidence to support this model by examining concurrently measured ASL, BOLD, and near-infrared spectroscopy to validate the calculated changes in underlying CMRO 2 .

Highly compact, filter-free multispectral photodetectors have important applications in biological imaging, face recognition, and remote sensing. In this work, we demonstrate room-temperature wavelength-selective multipixel photodetectors based on GaAs 0.94 Sb 0.06 nanowire arrays grown by metalorganic vapor phase epitaxy, providing more than 10 light detection channels covering both visible and near-infrared ranges without using any optical filters. The nanowire array geometry-related tunable spectral photoresponse has been demonstrated both theoretically and experimentally and shown to be originated from the strong and tunable resonance modes that are supported in the GaAsSb array nanowires. High responsivity and detectivity (up to 44.9 A/W and 1.2 × 10 12 cm √Hz/W at 1 V, respectively) were obtained from the array photodetectors, enabling highresolution RGB color imaging by applying such a nanowire array based single pixel imager. The results indicate that our filter-free wavelength-selective GaAsSb nanowire array photodetectors are promising candidates for the development of future high-quality multispectral imagers.

One highly desirable function of a diffraction grating is its ability to deflect incident light into a specific diffraction order with near-perfect efficiency. While such asymmetry can be achieved in a variety of ways, e.g., by using a sawtooth (blazed) geometry, a recently emerged approach is to use a planar metagrating comprised of designer multi-resonant periodic units (metamolecules). Here we demonstrate that a bianisotropic unit cell supporting four resonances interfering in the far field can be used as a building block for achieving the prefect deflection. A coupled mode analysis shows that these modes provide a small number of orthogonal electromagnetic radiation patterns that are needed to suppress transmission/reflection into all but one diffraction order. Bianisotropy caused by a mirror symmetry breaking enables a normally incident wave to excite, through near-field couplings, two otherwise "dark" resonant modes. We design and experimentally realize bianisotropic metamolecules which are sub-wavelength in all three dimensions, and whose optical properties are desensitized to fabrication imperfections by their geometric simplicity. We show that optical beams tightly focused onto the metagratings with just a few unit cells can also be asymmetrically deflected with high efficiency, paving the way for compact broadband optical devices.

Recently, III-V semiconductor nanowires have been widely explored as promising candidates for high-performance photodetectors due to their one-dimensional morphology, direct and tunable bandgap, as well as unique optical and electrical properties. Here, the recent development of III-V semiconductor-based single nanowire photodetectors for infrared photodetection is reviewed and compared, including material synthesis, representative types (under different operation principles and novel concepts), and device performance, as well as their challenges and future perspectives.