Ethanoanthracene cycloadducts (5–7) anti, (5–7) syn, and (5–7) dec have been synthesized from the Diels–Alder (DA) reaction of diene 1,8-dichloroanthracene 2, with the dienophiles; acrylonitrile 3, 1-cynavinyl acetate 4, and phenyl vinyl sulfone 5, individually. The steric effect of dienophile substituents were more favorable toward the anti-isomer formation as deduced from 1H-NMR spectrum. The cheminformatics prediction for (5–7) antiand (5–7) syn was investigated. The in silico anticipated anti-depression activity of the (5–7) antiand (5–7) syn compounds were investigated and compared to maprotiline 9 as reference anti-depressant drug. The study showed that steric interactions play a crucial role in the binding affinity of these compounds to the representative models; 4xnx, 2QJU, and 3GWU. The pharmacokinetic and drug-like properties of (5–7) antiand (5–7) synexhibited that these compounds could be represented as potential candidates for further development into antidepressant-like agents.
PurposeThis study provides a unique integrated diagnosis system to investigate the causes of low productivity, profitability, machinery health conditions and wear severity of medium-size biscuit industry assets in Taiz, Yemen.Design/methodology/approachThe evaluation is based on an integrating of the overall equipment effectiveness (OEE) and oil-based maintenance (OBM) approaches. The data are collected using the company's operational records, interviews and observations, while the used lubricating oil samples are also collected from production lines' machineries. Scanning electron microscope (SEM) is used to study the wear debris particle features and wear mechanism. Different other analysis tools such as fishbone, 5 whys and Pareto charts are also used to investigate the root causes and plausible recovery solutions of machinery failures.FindingsThis study demonstrated that a large proportion of machinery failures and production loss are of management concerns. Also, this study inferred that the analysis of wear debris is unique and informative for determining machinery wear severity and useful life. Finally, the current conditions of production lines are clarified and suggestions to use a mixed preventive/predictive maintenance management approach are also elucidated.Originality/valueThis work implemented an integrated OEE/OBM diagnostic maintenance system to investigate the root causes of low productivity and machine failures in real production lines and suggested robust decisions on the maintenance duties.
N-(Anthracen-9-ylmethyl)-N-methyl-2-(phenylsulfonyl)ethanamine 3 has been synthesized via the aza-Michael addition approach by reaction of the corresponding amine with the vinyl sulfone derivative under microwave conditions. The structure of the aza-Michael product 3 is elucidated by X-ray crystallography. The study of molecular packing by employing the Hirshfeld analysis indicates that the percentages of O…H, C…H and H…H contacts are 16.8%, 34.1% and 48.6%, respectively, where the O...H hydrogen bonds have the characteristics of short and strong contacts while the C...H contacts are considered weak. Density functional theory (DFT) investigations show that the aza-Michael product 3 is polar with a net dipole moment of 5.2315 debye.
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