We have successfully synthesized new oxovanadium (IV) complexes with dimedone derivatives and their structure were confirmed by elemental analyses, spectroscopic techniques (FT-IR, UV-visible, EPR) and thermal analysis. The reaction of [VO (acac) 2 ] with the azo dimedone ligands (HL n) produced mononuclear oxovanadium (IV) complexes with formula [VO (L n) 2 ] H 2 O. Results of the molar conductance proved that VO 2+ complexes are nonelectrolytes and fall in the range 14-16 Ω-1 cm 2 mol −1. The coordination geometry of VO (IV) complexes is square-pyramidal, where vanadium (IV) ion is coordinated by oxygen atom of the carbonyl (C=O) group, and nitrogen atom of the deprotonating hydrazone moiety (-NH-), while the fifth position is occupied by an oxo group. Moreover, the optimized structure, bond angles, bond lengths, as well as the calculated quantum chemical parameters of the complexes have been estimated. DNA binding activities of the complexes were investigated using electronic absorption titration and viscosity measurements. The obtained results showed groove binding of the complexes to CT-DNA accompanied with a partial insertion of the ligand between the base stacks of the DNA with a binding constant of 2.07-5.51 x 10 5 M −1 range. Evaluation results of the synthesized complexes against the human cancer cell lines HepG-2 and MCF-7, as compared to the positive controls in the viability assay of vinblastine and colchicine have been reported. The in vitro anti-oxidant activity of all the complexes is determined by DPPH free radical-scavenging assay. Finally, the anti-microbial activities of the complexes have been investigated against fungal (Candida albicans), gram negative bacteria (Escherichia coli), and gram positive bacteria (Staphylococcus aureus) using the discdiffusion method.

A simple spectrophotometric method is developed for the determination of phosphate in sugar cane juice, water and detergent samples. The method is based on the formation of phosphomolybdate with added molybdate followed by its reduction with sodium sulphide in aqueous sulfuric acid medium. The system obeys Lambert-Beer’s law at 715 nm in the concentration range 0.3-12.24 ppm. Molar absorptivity, correlation coefficient and Sandell’s sensitivity values were found to be 6.1x103mol-1cm-1, 0.999 and 0.0156 µg cm-2respectively. The results obtained were reproducible with acceptable standard deviation 3.7% and relative error 3.4%. For a comparison of the method phosphate present in various samples were also determined separately following an official method. The results of the developed method compare well with those of the official method.

Ethanoanthracene cycloadducts (5–7) anti, (5–7) syn, and (5–7) dec have been synthesized from the Diels–Alder (DA) reaction of diene 1,8-dichloroanthracene 2, with the dienophiles; acrylonitrile 3, 1-cynavinyl acetate 4, and phenyl vinyl sulfone 5, individually. The steric effect of dienophile substituents were more favorable toward the anti-isomer formation as deduced from 1H-NMR spectrum. The cheminformatics prediction for (5–7) antiand (5–7) syn was investigated. The in silico anticipated anti-depression activity of the (5–7) antiand (5–7) syn compounds were investigated and compared to maprotiline 9 as reference anti-depressant drug. The study showed that steric interactions play a crucial role in the binding affinity of these compounds to the representative models; 4xnx, 2QJU, and 3GWU. The pharmacokinetic and drug-like properties of (5–7) antiand (5–7) synexhibited that these compounds could be represented as potential candidates for further development into antidepressant-like agents.

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1 volumetric [6, 19] as well as other methods [12-16] when sulfur dioxide is in low concentrations, because of its simplicity and cost-effective instrumentation. However, one of the spectrophotometric methods [20] employs rosaniline and formaldehyde, which are considered to be toxic [21]. Another AOAC method [22] requires the use of the dye thymol blue, a known pH indicator. Obviously, the method requires the strict control of pH and also suffers from a narrow range of sulfur dioxide determination. Therefore, a new spectrophotometric method for sulfur dioxide is developed in our work. The method is based on the formation of a redbrown peroxovanadate complex [23-25], λ max = 470 nm, from ammonium metavandate and hydrogen peroxide in 2 M sulfuric acid. When sodium metabisulfite (Na 2 S 2 O 5 = 2SO 2) is added, it preferentially reacts with hydrogen peroxide, thereby decolorizing the peroxovanadate complex until its concentration is less than that of the complex.