Bio-Fabrication of Silver Nanoparticles Using &amp;lt;i&amp;gt;Catha edulis&amp;lt;/i&amp;gt; Extract: Procedure Optimization and Antimicrobial Efficacy Encountering Antibiotic-Resistant Pathogens

Numan, Abdulqawi; Ahmed, Mashhour; Galil, Mansour S. A.; Al-Qubati, Mohyeddine; Raweh, Ayman A.; Helmi, Enas A.

doi:10.4236/anp.2022.112004

Cited by 10 publications

(5 citation statements)

References 61 publications

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“…Reaction conditions, such as extract concentration, temperature, pH, and light intensity, can influence the production, characterization, and application of AgNPs [ 13 ]. Optimization of the reaction conditions can help produce nanoparticles with well-defined sizes and morphologies, thereby improving their properties [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Optimization, Characterization, and Anticancer Potential of Silver Nanoparticles Biosynthesized Using Olea europaea

Felimban

Alharbi

Alsubhi

2022

International Journal of Biomaterials

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Green synthesis has attracted significant attention as an eco-friendly, low-cost, energy-efficient, and non-toxic method for preparing silver nanoparticles (AgNPs) for cancer therapy. This study optimized the green synthesis of AgNPs using Olea europaea extracts and evaluated their anticancer potential. The biosynthesized AgNPs were characterized using various methods, showing stable AgNPs with a desirable morphology and high yield, improving the properties of AgNPs for various medicinal applications. The biosynthesized AgNPs were predominantly spherical, with small sizes ranging from 13 to 21 nm and highly stable at −23 and −24 mV. The findings of this study suggest that green-synthesized AgNPs using Olea europaea and sunlight possess significant anticancer activity against cancer cells in vitro. Further investigation of green synthesis would help to form high-quality AgNPs that have promising potential in treating disease and fighting undesirable pathogens.

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Section: Introductionmentioning

confidence: 99%

Optimization, Characterization, and Anticancer Potential of Silver Nanoparticles Biosynthesized Using Olea europaea

Felimban

Alharbi

Alsubhi

2022

International Journal of Biomaterials

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“…The presence of biomolecules from the P. aculeata L. aqueous extract attached to the surface of the synthesized materials is attributed to the agglomeration and cluster formation of Ag@Se-P and Ag@Se-S nanocomposites, which confirm the role of the P. aculeata L . aqueous extract as a reducing and capping agent ( Hassanin and Taha, 2022 ; Numan et al, 2022 ). Figures 2C, D show the elemental mapping obtained from EDS analysis for the produced Ag@Se-P and Ag@Se-S nanocomposites, respectively.…”

Section: Resultsmentioning

confidence: 99%

Cytotoxic activity of bimetallic Ag@Se green synthesized nanoparticles using Jerusalem Thorn (Parkinsonia aculeata)

Hassanin,

Taha,

Ibrahim

et al. 2024

Front. Chem.

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Introduction: The process of green synthesis of metal nanoparticles is considered to be eco-friendly and cost-effective.Methods: In this study, bimetallic Ag@Se-P and Ag@Se-S nanoparticles were synthesized successfully using Parkinsonia aculeata aerial parts and seed extracts. The phytochemical contents in P. aculeata aerial parts and seed aqueous extract serve as reducing and stabilizing capping agents without the need for any chemical stabilization additive in the synthesis of bimetallic nanoparticles.Result and Discussion: The obtained results from UV-vis spectrophotometry, scanning electron microscopy (SEM), X-ray powder diffraction (XRD), energy-dispersive X-ray spectroscopy (EDS), transmission electron microscopy (TEM), and Fourier-transform infrared spectroscopy (FT-IR) confirmed the successful synthesis of bimetallic nanoparticles with cluster irregular spherical morphology, crystalline nature, and average particle sizes of 17.65 and 24.36 nm for Ag@Se-S and Ag@Se-P, respectively. The cytotoxicity assessment of greenly synthesized nanomaterials using seed and plant extracts showed cell inhibition >50 μg/mL. Ag@Se-S and Ag@Se-P seed and plant extracts significantly reduced LPS-induced inflammation, which was assessed by NO and cytokines IL-1β, IL-6, and TNF-α. The mRNA and protein expression levels of phosphoinositide 3 kinase (PI3K) and nuclear factor kappa B (NFkB) were significantly overexpressed in LPS-induced RAW 264.7 cell lines. Ag@Se-S and Ag@Se-P downregulated the expression of PI3K and NFkB in LPS-induced cell models.

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“…Mariselvam et al [53] and Numan et al [54] consider zones of inhibition with sizes of < 9 mm, 9 - 12 mm, and 13 - 18 mm inactive, moderately active, and active, respectively. This study revealed that silver nanoparticles produced from methanolic and aqueous extracts of O. kilimandscharicum and crude extracts have significant antibacterial activity against Gram-positive and negative bacteria (Figure 14 and Table 3).…”

Section: Resultsmentioning

confidence: 99%

Silver nanoparticle biosynthesis utilizingOcimum kilimandscharicumleaf extract and assessment of its antibacterial activity against certain chosen bacteria

Ouandaogo,

Diallo,

Odari

et al. 2023

Preprint

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Using plants in the biological production of silver nanoparticles (AgNPs) is becoming increasingly important as a practical and environmentally benign method. In the current work, silver nanoparticles were made utilizing the significantOcimum kilimandscharicum, and their potential to combat certain bacteria was discussed. Both aqueous and methanol plant extracts were used for reducing silver nitrate at different time intervals (30 to 150 minutes) and pH (2 to 11). The UV-visible absorption spectrum recorded for both methanol and aqueous extracts revealed successful synthesis of AgNPs. The antimicrobial activity of the AgNPs was evaluated againstEscherichia coliATCC 25922,Salmonella choleraesuiusATCC 10708, andStaphylococcus aureusATCC 25923. 50mg/ml was the concentration of the extracts tested. The best zone of inhibition was recorded for the methanol and aqueous-mediated AgNPs, ranging from 12±1 to 16±1mm. The methanol and aqueous extract silver nanoparticles had the same Minimum Inhibitory Concentration (6.25±0.00 mg/ml), whereas the Minimum Bactericidal Concentrations were 12.5±0.00 and 25±0.00 mg/ml, respectively. The highest inhibition zone of 16±1 mm was observed againstSalmonella choleraesuiuswith 50±0.00 mg/ml aqueous silver nanoparticles. The results show that the silver nanoparticles made withOcimum kilimandscharicumhave potent antibacterial action against those microorganisms.

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Bio-Fabrication of Silver Nanoparticles Using <i>Catha edulis</i> Extract: Procedure Optimization and Antimicrobial Efficacy Encountering Antibiotic-Resistant Pathogens

Cited by 10 publications

References 61 publications

Optimization, Characterization, and Anticancer Potential of Silver Nanoparticles Biosynthesized Using Olea europaea

Optimization, Characterization, and Anticancer Potential of Silver Nanoparticles Biosynthesized Using Olea europaea

Cytotoxic activity of bimetallic Ag@Se green synthesized nanoparticles using Jerusalem Thorn (Parkinsonia aculeata)

Silver nanoparticle biosynthesis utilizingOcimum kilimandscharicumleaf extract and assessment of its antibacterial activity against certain chosen bacteria

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