Gharibzahedi S.M.T., Razavi S.H., Mousavi M. (2014): Enzymatically hydrolysed molasses and sodium citrate as new potentials for the improvement of canthaxanthin batch synthesis by Dietzia natronolimnaea HS-1: A statistical media optimisation. Czech J. Food Sci., 32: 326-336.Response surface methodology-central composite rotatable design (RSM-CCRD) was applied to explore the optimum media formulation for maximising canthaxanthin (CTX) biosynthesis by dietzia natronolimnaea HS-1. The effects of three variables of enzymatically hydrolysed molasses (EHM) (16.6-33.4 g/l), sodium (Na)-citrate (21.64-28.36mM), and yeast extract (6.32-9.68 g/l) concentrations on the production of CTX, total carotenoid (TCT), and biomass dry weight (BDW) were appraised. The results showed that the quadratic effects of EHM, yeast extract, and Na-citrate contents in terms of second-order polynomial regression equations (r 2 = 0.968-0.986), respectively, had the most significant effects on the produced TCT and CTX. The predicted maximum accumulation of BDW (8.88 g/l), TCT (7.24 mg/l), and CTX (6.40 mg/l) under the optimum concentrations of the media variables (26.16 g/l EHM, 8.29 g/l yeast extract, and 25.86mM Na-citrate) was very close to the experimental values determined in batch experiments. The high BDW content suggested EHM and Na-citrate as very promising feedstocks for CTX bioproduction by the bacterium studied.
Interstitial fluid flow has been studied by many cancer researchers for investigation of how interstitial flow can affect drug delivery. This paper couples blood flow through a capillary network induced by tumor angiogenesis and fluid flow in interstitium and investigates the effects of consideration of a remodeled network and adaptability of capillary on interstitial flow. Two approaches are studied for showing the remodeling effects. In the first approach, the capillary network is presumed to have capillary with constant diameter. For the second approach, the adaptable capillaries are assumed in which the metabolic and hemodynamic stimuli changes capillary's diameter based on sending signals to capillary. Numerical results show that the intravascular pressure has more uniform distribution along the network and capillary diameter has greater value in the network. The prediction of interstitial pressure for the second approach shows higher values compared to the first approach. Results from interstitial flow and blood flow distribution in normal and cancerous tissues have beneficial information about prediction of successive drug delivery.
We have investigated energy levels mirror nuclei of the 17 O and 17 F in relativistic and nonrelativistic shell model. The nuclei 17 O and 17 F can be modeled as a doubly-magic 17 O=n+(N=Z=8) and 17 F=p+(N=Z=8), with one additional nucleon (valence) in the ld5/2 level. Then we have selected the quadratic Hellmann potential for interaction between core and single nucleon. Using Parametric Nikiforov-Uvarov method, we have calculated the energy levels and wave function in Dirac and Schrodinger equations for relativistic and non-relativistic, respectively. Finally, we have computed the binding and excited energy levels for mirror nuclei of 17 O and 17 F and compare with other works. Our results were in agreement with experimental values and hence this model could be applied for similar nuclei.
Piezoelectric polymers have emerged as promising materials for application in pressure sensing devices in particular for wearable applications, where inorganic piezoelectric materials can face limitations due to their brittleness. One of the bottlenecks for the adaptation of piezoelectric polymers is their relatively weak piezoelectric voltage coefficient. Hence there have been numerous efforts to improve the performance of the comprising devices by making composites of poly(vinylidene fluoride) (PVDF), or through making porous PVDF films, or by nanostructuring. Here, we demonstrate the fabrication of porous nanofibers with graphene/PVDF composites and investigate the suitability of the fiber for motion sensing. The nanofibers are fabricated by electrospinning from the solution phase. Guided by an experimentally validated phase diagram for PVDF/solvent/non-solvent ternary system, porous graphene/PVDF nanofibers with different porosities and pore morphologies have been produced through solidifying the fibers in the binodal or spinodal regions of the phase diagram.It is found that only by solidifying the composite fibers in the spinodal region, graphene loading of 0.1 wt% promotes the formation of the electroactive phase substantially, and the resulting fibers exhibit enhanced piezoelectric output. It is further shown that the comprising sensors are biocompatible and show high sensitivity to body motion.
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