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Newer cancer treatment modalities have increased patient survival rate and longevity. Craniofacial and dental abnormalities occurring after radiation therapy and surgery in cancer patients may lead to severe cosmetic or functional sequelae, which may require surgical or orthodontic intervention later on. We, present a case; who was treated for retinoblastoma with enucleation of left eye and external beam radiotherapy at 26 months of age. As a result of radiotherapy there was hypoplasia of the maxilla. This case validates Von-Limborg's theory that states that local epigenetic factor like the developing eye has an important influence on the growth of adjacent structures, as with this patient there was hypoplasia of left orbit. Certain dental anomalies were also seen in the maxillary arch.

Dental hard tissue is subject to variety of disorders. Dentinogenesis Imperfecta is one such disorder attributed to heredity. It is known to be an autosomal dominant trait. Teeth with such ‘imperfect’ dentin are liable to be weak and discolored. The disease has variable penetration and therefore can be expressed as a range of phenotypic manifestations from mild discoloration and chipping to frank attrition and multiple pulp canal exposures. Here we present a comparative study of a series of cases from different families of one topographical region with widely different presentation and histories that are characteristic of this disease.

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