Long term dento-facial effects of radiotherapy in a treated patient of retinoblastoma

Khan, Saba; Maheshwari, Sandhya; Khan, Mohd Toseef; Verma, Sanjeev

doi:10.1016/j.jobcr.2014.11.001

Cited by 4 publications

(2 citation statements)

References 6 publications

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“…Retinoblastoma is the eye carcinoma that develops rapidly and can either be heritable or inheritable [7]. A heritable retinoblastoma typically presents in younger patients commonly younger than the age of one year whereas the inheritable type presents in patients who are older than the age of one year [8,9].…”

Section: Discussionmentioning

confidence: 99%

Unusual presentation of a retinoblastoma: A rare case

Gaxa¹,

Hlatshwayo²

2015

Case Rep Int

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Introduction: Although a retinoblastoma is a well recognized condition it is still associated with a high mortality rate especially in developing countries because partly patients tend to present at very late stages to the health facilities. the mean age of occurrence of a retinoblastoma is 18 months and the age range of a retinoblastoma occurrence is 0-5 years. Diagnosing a retinoblastoma above the age of six years is extremely rare and exceptional. case report: An eight-year-old girl was presented with a six-month history of a fast growing right eye mass and proptosis. the mass was fungating and septic. the patient had normal developmental milestones. At presentation the body weight 21.40 kg.the vital signs were within normal limits (temperature 36.8°c, pulse 83 beats/min, blood pressure 116/77 mmHg). the diagnosis of a retinoblastoma was highly suspected on clinical and radiological imaging but due to patient's age there was also a suspicion of a rhabdomyosarcoma of the orbit. biopsy was performed and the diagnosis of a retinoblastoma was confirmed and the patient was then started on chemotherapy. the patient later demised

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Section: Discussionmentioning

confidence: 99%

Unusual presentation of a retinoblastoma: A rare case

Gaxa¹,

Hlatshwayo²

2015

Case Rep Int

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“…These include hypoplasia, hyperpigmentation, or soft tissue fibrosis. Long-term dentofacial anomalies have also been reported [36,38,40].…”

Section: External Beam Radiation Therapy (Ebrt)mentioning

confidence: 99%

Retinoblastoma: Update on Current Management

Almater¹,

Alfaleh²,

Alshomar³

et al. 2019

Retinoblastoma - Past, Present and Future

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Retinoblastoma (Rb) is the most common primary intraocular malignancy in children with an incidence from 1:15,000 to 1:20,000 live births. It can present as a unilateral or bilateral involvement of the eyes. It is generally induced by biallelic mutation of the RB1 tumor suppressor gene that leads to malignant transformation of primitive retinal cells. The most common presentation is leukocoria, followed by strabismus. The initial assessment and future treatment of such tumor should be based on the laterality, the stage of the tumor, and the presenting age of the child. In general, the primary target of therapy is to preserve the child's life. However, preserving the globe and preserving vision should be achieved whenever it's possible. Retinoblastoma treatment has evolved from enucleating the affected globe to also involving external beam radiation therapy, cryotherapy, laser photocoagulation, thermotherapy, brachytherapy, and chemotherapy (intravitreal, intra-arterial, and systematic). This chapter is intended to discuss briefly the clinical presentation of Rb, as well as a comprehensive review about the evolution and current treatment modalities with a focus on cases with low-risk features.

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