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Mono and bi-organometallic complexes of Cu(II), Ni(II), Mn(II), Zn(II) and Ag(I) complexes with oxaloamide ligand has much potential as therapeutic and diagnostic agents. The ligand allows the thermodynamic and kinetic reactivity of the metal ion to be controlled and also provide a scaffold for functionalization. Specific examples involving the design of metal complexes as anticancer agents are discussed. These complexes have been synthesized and characterized by (1H-NMR, mass, IR, UV-VIS, ESR) spectra, magnetic moments and conductance measurements, elemental and thermal analyses. Molar conductances in DMF solution indicates that, the complexes are non-electrolytes. The ESR spectra of solid Cu(II) complexes (2-5) show an axial type indicating a d(X2-y2) ground state with a significant covalent bond character. However, Mn(II) complex(9), shows an isotropic type indicating an octahedral geometry. Cytotoxic evolution IC50 of the ligand and its complexes have been carried out. Cu(II) Complexes

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New series of Mn(II), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) organometallic complexes with hydroxyl benzylidene malonohydrazide ligand have much potential as therapeutic and diagnostic agents. The ligand allows the thermodynamic and kinetic reactivity of the metal ion to be controlled and also provide a scaffold for functionalization. The establishment of structure activity relationships and elucidation of the specification of complexes under conditions relevant to drug testing and formulation are crucial for the further development of promising medicinal applications of organometallic complexes. Specific examples involving the design of metal complexes as anticancer agents are discussed. These complexes have been synthesized and characterized by ( 1 H-NMR, mass, IR, UV-VIS and ESR) spectroscopy, as well as magnetic moments, conductance, elemental and thermal analyses. Molar conductance in DMF solution indicates that, the complexes are non-electrolytes. The ESR spectra of solid Cu(II) complexes (7) and (8) showed isotropic and anisotropic types indicating an octahedral geometry with covalent bond character. However, Co(II) complexes (3) and (4) showed anisotropic type where, g┴ > g|| >2.0023, indicating compressed tetragonal distortion around Co(II) ion. Cytotoxic evolution of the ligand and its complexes have been carried out. Complexes showed enhanced activity in comparison to the parent ligand or standard drug applied

This study determined the selective cytotoxicity and mutagenic potential of novel Schiff base complex nanoparticles of copper salt. Chemotherapeutic study of this complex nanoparticles both invitro and invivo in the treatment of hepatocellular carcinoma induced in rats had been done. The treatment efficacy of the studied complex nanoparticles was evaluated by measuring antioxidant activities against oxidative stress caused by diethyl nitrosamine in liver tissue. The measurements included reduced glutathione content, superoxide dismutase activity, total antioxidant capacity, as well as malondialdehyde level. Liver and kidney function tests were also determined, in addition to the evaluation of serum alpha-fetoprotein. Histopathological studies were also performed for liver, spleen, kidney, lung and testis tissues. Results showed that the metal complex nanoparticles had a high potency in the treatment of hepatocellular carcinoma which induced by diethyl nitrosamine in rats as it ameliorated from the investigated parameters toward normal control animals. These findings were well appreciated with histopathological studies of diethylnitrosamine group treated with the complex nanoparticles. It was found that the complex nanoparticles under study can interact with antioxidant to form cancer-specific proteasome inhibitors and apoptosis inducers in liver cancer cell.