Metallo-organic Copper(II) Complex in Nano Size as a New Smart Therapeutic Bomb for Hepatocellular Carcinoma

El‐Tabl, Abdou Saad; Wahed, Moshira M. Abd-El; Ashour, Ahmed M.; Abu-Setta, Mohammed H. H.; H.Hassanein, Omar; Saad, Amr Abdou

doi:10.29055/jccs/695

Cited by 5 publications

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“…Reports indicate that Cu complex NPs might be useful as therapeutics in cancer therapy, and Cu complex NPs in combination with Hadron therapy led to an enhancement of strongly lethal DNA damage caused by double-strand breaks. A previous study showed that Cu complex NPs uptake by the cells endocytosis and emphasized intracellular release of Cu 2+ blocks cell division by binding to DNA causing DNA damage and contributed to the cytotoxicity and metabolic stress activating cell death via apoptosis [41]. Cu complex NPs produces a cytotoxic effect by reducing cell viability and causing inter-nucleosomal DNA fragmentation, G2/M cell-cycle arrest, and hypo-diploid accumulation emphasizing that they have potential anticancer properties and can be applied as cancer therapeutics [42].…”

Section: Discussionmentioning

confidence: 99%

Cytotoxicity and antitumor activity of organometallic copper (II) Nano particles in a chemically induced hepatocellular carcinoma rat model

El‐Tabl

Wahed

Abu-Setta

et al. 2022

Preprint

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This study determined the selective cytotoxicity and mutagenic potential of novel Schiff base complex nanoparticles of copper salt. Chemotherapeutic study of this complex nanoparticles both invitro and invivo in the treatment of hepatocellular carcinoma induced in rats had been done. The treatment efficacy of the studied complex nanoparticles was evaluated by measuring antioxidant activities against oxidative stress caused by diethyl nitrosamine in liver tissue. The measurements included reduced glutathione content, superoxide dismutase activity, total antioxidant capacity, as well as malondialdehyde level. Liver and kidney function tests were also determined, in addition to the evaluation of serum alpha-fetoprotein. Histopathological studies were also performed for liver, spleen, kidney, lung and testis tissues. Results showed that the metal complex nanoparticles had a high potency in the treatment of hepatocellular carcinoma which induced by diethyl nitrosamine in rats as it ameliorated from the investigated parameters toward normal control animals. These findings were well appreciated with histopathological studies of diethylnitrosamine group treated with the complex nanoparticles. It was found that the complex nanoparticles under study can interact with antioxidant to form cancer-specific proteasome inhibitors and apoptosis inducers in liver cancer cell.

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Section: Discussionmentioning

confidence: 99%

Cytotoxicity and antitumor activity of organometallic copper (II) Nano particles in a chemically induced hepatocellular carcinoma rat model

El‐Tabl

Wahed

Abu-Setta

et al. 2022

Preprint

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“…Kivelson and Neiman noted that, for an ionic environment, g is normally 2.3 or larger but for covalent environment gis less than 2.3. The values of the present complexes are less than 2.3, so there a significant degree of covalence in the metalligand bonding [58]. The σparameter (  2 ) was calculated from the following equations  2 = (g -2.0023) + 3/7 (g-2.0023) -(P) + 0.04…….….…(1) Where P is the free ion dipolar term which is equal 0.036, A is the parallel coupling constant expressed in cm -1 .…”

Section: Electron Spin Resonance (Esr)mentioning

confidence: 98%

Nano metal complexes in cancer therapy, preparation, spectroscopic, characterization and anti-breast cancer activity of new metal complexes of alanine Schiff-base.

et al. 2021

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There are many properties of metal ions that were useful for solving basic problems in medicine, metal complexes with particular properties can be covalently affected to biological macromolecules. Mono Co(II), Ni(II) ,Cu(II) ,Zn(II) ,Mg(II) and binuclear Zn(II)/Cu(II) and Ni(II)/Cu(II) complexes of new Schiff-base derived from alanine amino acid ester have been synthesized and characterized. They were studied using elemental and spectral analysis such as IR,UV-VIS, 1 H-NMR mass spectroscopy as well as conductivity, magnetism, thermal analysis (DTA and TGA), electron microscope and ESR measurements. Conductance measurements of metal complexes indicated non electrolytic in nature. Elemental and spectral analysis confirmed distorted octahedral structural for all complexes. ESR spectra of complexes showed anisotropic or isotropic spectra with covalent bond character. Electron microscope data showed that, complexes with high biological activity were found in Nano form. The ligand and some of its complexes were studied against breast cancer (in vitro) and exhibited moderate to high activity compared to standard drug (doxorubicin). The order of activity was (doxorubicin)= ligand (1) > Ni(II)/Cu(II) complex (19) > Zn(II)/Cu(II) complex (20) > Zn(II) complex (18).

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“…In vitro biological screening test for ligand (1) and its metal complexes (2), (3), (4), ( 6), ( 8), (10), (11), ( 12) and (14) performed as antibacterial and antifungal activity (Figures 3 and 4). Antibacterial activity was tested against two bacterial strains; Gram-positive Staphylococcus aureus as well as Gram-negative strains of Escherichia coli [58][59][60]. The results were compared to the standard drug Ampicllin (Gram positive) and Amphotericin B (Gram negative).…”

Section: Antimicrobial Activitymentioning

confidence: 99%

Physico-chemical Characterization and Estimation of Antimicrobial Activity of Modified Aspirin in the form of Nano-organometallic Compounds

El‐Tabl

El-Wahed

Ahmed³

et al. 2022

CSIJ

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Aspirin is one of the most commonly used drugs. It is necessary to find and develop analgesic anti- inflammatory drugs that are safe against their adverse effects. From this standpoint, new nano- organometallic Cu(II), Mn(II), Ni(II), Cd(II) and Zn(II) compounds of modified aspirin were prepared and characterized using elemental and spectroscopic techniques such as infrared and ultraviolet, proton nuclear magnetic resonance, mass spectroscopy, electron spin resonance and electron microscope, as well as magnetism, conductivity and thermal analysis. Thermal and spectral results showed the octahedral geometry and stability of these compounds up to 45oC. The data indicated that, using low concentration against microbes, aspirin and ligand no effect was observed, however, the complexes showed moderate to high effect, The order for Gram positive is Cd(II) complex (10)> Cd(II) complex (11)> ampicillin> Zn(II) complex (8)> Cu(II) complex (4)> Cu(II) complex (6)= Ni(II) complex (12)> Cu(II) complex (2) = Cu(II) complex (3)> ligand (1)> aspirin> Mn(II)complex(14) and for Gram negative is ampicillin> Cd(II) complex (10)> Cd(II) complex (11)> Cu(II) complex (2) > Cu(II) complex (6)> Cu(II) complex (3)> Cu(II) complex (4) > Zn(II) complex (8)> aspirin> Ni(II) complex (12) > ligand (1)> Mn(II) complex (14) and for Aspergillus flavus is Cd(II) complex (10)>amphotericin B> Cd(II) complex (11)> ligand (1)= aspirin= Cu(II) complex (2)= Cu(II) complex (3)= Cu(II) complex (4)= Cu(II) complex (6) = Zn(II) complex (8)= Ni(II) complex (12)= Mn(II) complex (14) and for Candida albicans is Cd(II) complex (10)> Cd(II) complex (11)> amphotericin B > Ni(II) complex (12)> Cu(II) complex (3)= Cu(II) complex (6)> Cu(II) complex (2)= Cu(II) complex (4)> ligand(1) = aspirin= Zn(II) complex (8)= Mn(II) complex (14). The order of the catalytic effect of the tested complexes on decomposition of H2O2 was Mn(II) complex (14)> Ni(II) complex (12) > Cu(II) complex (4) > Cu(II) complex (6)> Cu(II) complex (2) respectively.

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Metallo-organic Copper(II) Complex in Nano Size as a New Smart Therapeutic Bomb for Hepatocellular Carcinoma

Cited by 5 publications

References 0 publications

Cytotoxicity and antitumor activity of organometallic copper (II) Nano particles in a chemically induced hepatocellular carcinoma rat model

Cytotoxicity and antitumor activity of organometallic copper (II) Nano particles in a chemically induced hepatocellular carcinoma rat model

Nano metal complexes in cancer therapy, preparation, spectroscopic, characterization and anti-breast cancer activity of new metal complexes of alanine Schiff-base.

Physico-chemical Characterization and Estimation of Antimicrobial Activity of Modified Aspirin in the form of Nano-organometallic Compounds

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