Two sesquiterpenoid compounds, 4(15)-eudesmen-1,6-diol (1) and spathulenol (2) have been isolated from the stembark of Aglaia minahassae belong to Meliaceae family. The chemical structures of 1 and 2 were identified on the basis of spectroscopic evidence including UV, IR, NMR 1D, NMR 2D as well as mass spectra and by comparison with those previously reported spectra data. This compounds were isolated from this plant for the first time.
Previous phytochemical studies from the Aglaia genus reported the presence of terpenoid compound. This research describes the isolation and structure elucidation of sesquiterpend compound from the stembark of Aglaia simplicifolia. Dried stembark of A. simplicifolia extracted with methanol and then partitioned with n-hexane, ethyl acetate, and n-butanol, respectively. The n-hexane extract then was separated and purified with chromatography techniques to obtain isolated compound. The chemical structure of isolated compound was elucidated by IR, NMR 1D, NMR 2D as well as mass spectra and by comparison with those previously reported spectra data. The compound identified as senecrassidiol. This compound showed cytotoxicity activity against HeLa cervical cancer cells with IC50 values of 2.18 µM.
Resin glycoside is a type of secondary metabolite isolated commonly from the Convolvulaceae family. It consists of oligosaccharides conjugated to organic acids with a larger percentage having a macrocyclic structure. The resin glycosides reported in this review is classified mostly based on the number of sugar units constructing the structure, which is correlated to the biological properties of the compounds. According to preliminary reviews, the protocols to isolate the compounds are not straightforward and require a special technique. Additionally, the structural determination of the isolated compounds needs to minimize the structure for the elucidation to become easier. Even though resin glycosides have a complicated structural skeleton, several total syntheses of the compounds have been reported in articles published from 2010 to date. This review is an update on the prior studies of the resin glycosides reported in 2010 and 2017. The review includes the classification, isolation techniques, structural determination, biological properties, and total synthesis of the resin glycosides.
Lansium domesticum Corr. (L. domesticum), Meliaceae, has an economical fruit found throughout the southeast and has been reported to be used in traditional medicine. Therefore, this study aims to investigate the antimicrobial and cytotoxic potential of four extracts from the stembark of L. domesticum Corr. cv. Kokossan and isolated four terpenoid compounds. Antimicrobial testing was performed on two fungi, namely Malassezia furfur and Candida albicans, and two bacteria, Staphylococcus epidermidis and Klebsiella pneumoniae. Furthermore, antimicrobial activity was determined using the minimum inhibitory concentration (MIC). All isolated extracts were also tested on MCF-7 breast cancer cells. The results showed that butanol and n-hexane extracts have antimicrobial potential against K. pneumoniae bacteria with MIC values of 7.8125 mg/mL and 62.5 mg/mL, respectively, as well as against the dandruff fungus M. furfur. In addition to the antimicrobial results, the anticancer test results also showed that n-hexane has the most interesting cytotoxic value of all extracts, with an IC50 of 42.95 µg/mL than extracts of ethyl acetate, ethanol, and butanol with respective IC50 values of 72.84; 74.50, and 12088.33 µg/mL. The n-hexane and n-butanol extracts have anticancer and antimicrobial potential. These extracts can be studied further for other bioactivity.
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