Sesquiterpenoid Compounds from The Stembark of Aglaia minahassae (Meliaceae)

Abstract

Two sesquiterpenoid compounds, 4(15)-eudesmen-1,6-diol (1) and spathulenol (2) have been isolated from the stembark of Aglaia minahassae belong to Meliaceae family. The chemical structures of 1 and 2 were identified on the basis of spectroscopic evidence including UV, IR, NMR 1D, NMR 2D as well as mass spectra and by comparison with those previously reported spectra data. This compounds were isolated from this plant for the first time.

Cytotoxic Sesquiterpenoids from the Stem Bark of <i>Aglaia harmsiana</i> (Meliaceae)

“…3). The detailed examination of the NMR spectral data and comparison with those reported for 4α,10α-dihydroxyaromadendrane [14,16] showed that the structures of these two compounds are very similar. Therefore, the structure of compound 3 was determined to be 4α,10α-dihydroxyaromadendrane.…”

“…A. harmsiana is one of Aglaia plants that has been phytochemically investigated before and it has been proven to contain cycloartane triterpenoids [11][12] and rocaglamide derivative with insecticidal activity [13]. In total, less than ten aromadendrane-type sesquiterpenoids were investigated separately from the Aglaia species [14][15], and this type of compound did not attract considerable attention [16].…”

Caryophyllene-Type Sesquiterpenoids from the Stembark of Aglalia harmsiana and Their Cytotoxic Activity Against MCF-7 Breast Cancer Cells

“…These functionalities accounted for one out of the total four hydrogen deficiency index. Three remaining hydrogen deficiency index was corresponded to the tricyclic sesquiterpenoid structure and one cyclic comes from an epoxide group (Kurniasih et al, 2018;Roux et al, 1998;Liu et al, 2014).…”

“…Aglaia species which have been shown to contain sesquiterpenoid compounds are A. minahassae (Kurniasih et al, 2018), A. foveolata (Roux et al, 1998), A. odorata (Liu and Xu, 2016), A. silvestris (Poitinger et al, 2008), A. grandis (Inada et al, 2000), A. perviridis (Pan et al, 2013) and A. leucophylla (Benosman, Richomme, Sevenet, Hadi & Bruneton, 1994) with six sesquiterpenoid groups, namely sesquiterpenoid eudesmane, guaiane, aromadendrane, cadinene, isodaucane, and caryophyllene. Caryophyllene-type sesquiterpenoids, particularly caryophyllene oxide, has showed cytotoxic activity against various cancer cell lines, such as HepG2, AGS, HeLa, SNU-1, and SNU-16 (Jun et al, 2011) Although sesquiterpenoids of other Aglaia species have been investigated previously, the sesquiterpenoid compounds of the stem bark of A.…”

Phytochemistry and Pharmacology of <i>Munronia</i> Genus (Meliaceae)

“…Meliaceae is well known as a source of diverse natural compounds with interesting biological activity. Some compounds including sesquiterpenoids [2][3][4][5][6][7], triterpenoids [8][9][10][11][12][13][14][15][16][17][18], diterpenoids [19][20][21], steroids [22][23][24][25], limonoids [26][27], alkaloids [28][29], lignan [30][31][32], flavaglines [33][34][35], and flavonoids [36][37] have been successively extracted from this family. Those isolated compounds showed interesting biological activities including cytotoxic [38][39][40][41], insecticidal [42][43], antimycobacterial [6], antifungal [44][45], antiinflammatory [9,[46]…”