Cytotoxic sesquterpenoid compound from the stembark of Aglaia simplicifolia (Meliaceae)

Kurniasih, Nunung; Supriadin, Asep; Fajar, Mohamad; Abdulah, Rizky; Harneti, Desi; Supratman, Unang; Taib, Mehdi

doi:10.1088/1742-6596/1402/5/055037

Cited by 3 publications

(3 citation statements)

References 4 publications

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“…The minor tricyclic sesquiterpenoid ( 194 ) also demonstrated selective cytotoxicity against HeLa using Resazurin assay with cisplatin as a positive control (IC 50 value 2.18 µM), while the derivate compound ( 195 ) cytotoxicity was also evaluated against human liver cancer HepG using SRB assay and the result was inactive compared to camptothecin as the positive control [ 118 , 173 ].…”

Section: Biological Activitymentioning

confidence: 99%

Sesquiterpenoids from Meliaceae Family and Their Biological Activities

2023

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Sesquiterpenoids, an important class of natural products possessing three isoprene-derived units, are widely distributed across plants and have a variety of biological activities. All sesquiterpenoids are derived from farnesyl pyrophosphate (FPP), a biosynthesis precursor that can form various carbon skeletons. In order to provide a reference for further research and development of these compounds, this review focused on the increasing number of isolated and volatile sesquiterpenoids found to be produced by plants of the Meliaceae family between 1968 and 2023. The related articles were collected from SciFinder, Google Scholar, and PubMed. According to a literature review, several studies were started for more than 55 years on the plant’s stem barks, twigs, leaves, flowers, seeds, and pericarps, where approximately 413 sesquiterpenoid compounds from several groups such as eudesmane, aromadendrane, cadinane, guaiane, bisabolane, furanoeremophilane, humulene, germacrane, and oppositane-type were isolated and identified with some minor products. Additionally, the hypothetical route of sesquiterpenoids biosynthesis from this family was identified, and eudesmane-type was reported to be 27% of the total compounds. The antimicrobial, antidiabetic, antioxidant, antiplasmodial, antiviral, and cytotoxic activities of the isolated compounds and major volatile sesquiterpenoids constituent on essential oil were also evaluated. The result showed the fundamental of using the sesquiterpenoid compounds from the Meliaceae family in traditional medicine and the discovery of new drugs.

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Section: Biological Activitymentioning

confidence: 99%

Sesquiterpenoids from Meliaceae Family and Their Biological Activities

2023

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“…A. simplicifolia is one of Aglaia plants that has been phytochemically investigated before, and it has been proven to contain ergosterol peroxide, stigmasterol, and senecrassidiol with cytotoxic activity against HeLa cervical cancer [15][16]. So far, about twenty-three sesquiterpenoids have been investigated separately from the Aglaia species [13].…”

Section: ■ Introductionmentioning

confidence: 99%

Sesquiterpenoids from the Stem Bark of <i>Aglaia simplicifolia</i> and Their Cytotoxic Activity against B16-F10 Melanoma Skin Cancer Cell

et al. 2021

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Four sesquiterpenoid derivatives, i.e., 4β,10α-dihydroxyaromadendrane (1), caryophyllenol-II (2), senecrassidiol (3), and clovane-2β,9α-diol (4) have been isolated from the stem bark of Aglaia simplicifolia. The chemical structures of compounds 1-4 were determined based on spectroscopic data, including one and two-dimensional NMR and mass spectroscopy. In addition, these sesquiterpenoids 1-4, were also tested for their cytotoxic activity against B16-F10 melanoma skin cancer cell lines through in vitro assay. Among the isolated compounds 1-4, compound 1 showed the highest activity with an IC50 value of 44.8 μg/mL, suggesting the presence of a cyclopropane ring that plays an essential role in cytotoxic activity against B16-F10 melanoma skin cancer cell lines.

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“…Aglaia simplicifolia is found in Sumatra and Kalimantan, Indonesia. So far, reports on the content of secondary metabolite compounds from this plant are the only senecracidiol isolated from the bark of the stem (Kurniasih et al, 2019). Although steroids of other Aglaia species have been investigated previously, the ergosterol peroxide of A. simplicifolia is yet to be reported.…”

Section: Introductionmentioning

confidence: 99%

Ergosterol Peroxide and Stigmasterol from The Stembark of Aglaia simplicifolia (Meliaceae) and Their Cytotoxic against HeLa Cervical Cancer Cell Lines

Kurniasih¹,

Supriadin²,

Harneti³

et al. 2021

Valensi

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Two steroid compounds, ergosterol peroxide (1) and stigmasterol (2) have been isolated from the stembark of Aglaia simplicifolia belong to Meliaceae family. The chemical structures of 1 and 2 were identified based on spectroscopic evidence including UV, IR, 1D NMR, 2D NMR as well as mass spectra and by comparison with those previously reported spectra data. Both compounds were evaluated for their cytotoxic effects against cervical cancer HeLa cells in vitro. Compounds 1 and 2 showed cytotoxicity activity against HeLa cervical cancer cells with IC50 values of 0.80 and 26.42 µM, respectively.

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Cytotoxic sesquterpenoid compound from the stembark of Aglaia simplicifolia (Meliaceae)

Cited by 3 publications

References 4 publications

Sesquiterpenoids from Meliaceae Family and Their Biological Activities

Sesquiterpenoids from Meliaceae Family and Their Biological Activities

Sesquiterpenoids from the Stem Bark of <i>Aglaia simplicifolia</i> and Their Cytotoxic Activity against B16-F10 Melanoma Skin Cancer Cell

Ergosterol Peroxide and Stigmasterol from The Stembark of Aglaia simplicifolia (Meliaceae) and Their Cytotoxic against HeLa Cervical Cancer Cell Lines

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