Ergosterol Peroxide and Stigmasterol from The Stembark of Aglaia simplicifolia (Meliaceae) and Their Cytotoxic against HeLa Cervical Cancer Cell Lines

Abstract

Two steroid compounds, ergosterol peroxide (1) and stigmasterol (2) have been isolated from the stembark of Aglaia simplicifolia belong to Meliaceae family. The chemical structures of 1 and 2 were identified based on spectroscopic evidence including UV, IR, 1D NMR, 2D NMR as well as mass spectra and by comparison with those previously reported spectra data. Both compounds were evaluated for their cytotoxic effects against cervical cancer HeLa cells in vitro. Compounds 1 and 2 showed cytotoxicity activity against HeLa cervical cancer cells with IC50 values of 0.80 and 26.42 µM, respectively.

Phytochemicals from Pterocarpus angolensis DC and Their Cytotoxic Activities against Breast Cancer Cells

“…The isolated stigmasta-5-22-dien-3-ol ( 5 ) and tetradecyl ( E )-ferulate ( 8 ), with IC 50 values of 226.9 µM and 223.1 µM, respectively, did not show any cytotoxicity activity against MCF-7 ( Table 1 ). In another study, Stigmasta-5-22-dien-3-ol ( 5 ) showed cytotoxicity effects against oral epithelial carcinoma cells (KB/C152) with an IC 50 value of 81.18 μg/mL [ 20 ] and against HeLa cervical cancer cells with an IC 50 value of 26.42 µM [ 35 ]. (3 β )-3-Acetoxyolean-12-en-28-oic acid ( 7 ) and tetradecyl ( E )-ferulate ( 8 ) exhibited low cytotoxicity against triple-negative breast cancer (HCC70) with IC 50 values of 146.8 µM and 128.2 µM, respectively.…”