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Introduction Some local protocols suggest using intermediate or therapeutic doses of anticoagulants for thromboprophylaxis in hospitalized patients with coronavirus disease 2019 (COVID‐19). However, the incidence of bleeding, predictors of major bleeding, or the association between bleeding and mortality remain largely unknown. Methods We performed a cohort study of patients hospitalized for COVID‐19 that received intermediate or therapeutic doses of anticoagulants from March 25 to July 22, 2020, to identify those at increased risk for major bleeding. We used bivariate and multivariable logistic regression to explore the risk factors associated with major bleeding. Results During the study period, 1965 patients were enrolled. Of them, 1347 (69%) received intermediate‐ and 618 (31%) therapeutic‐dose anticoagulation, with a median duration of 12 days in both groups. During the hospital stay, 112 patients (5.7%) developed major bleeding and 132 (6.7%) had non‐major bleeding. The 30‐day all‐cause mortality rate for major bleeding was 45% (95% confidence interval [CI]: 36%‐54%) and for non‐major bleeding 32% (95% CI: 24%‐40%). Multivariable analysis showed increased risk for in‐hospital major bleeding associated with D‐dimer levels >10 times the upper normal range (hazard ratio [HR], 2.23; 95% CI, 1.38–3.59), ferritin levels >500 ng/ml (HR, 2.01; 95% CI, 1.02–3.95), critical illness (HR, 1.91; 95% CI, 1.14–3.18), and therapeutic‐intensity anticoagulation (HR, 1.43; 95% CI, 1.01–1.97). Conclusions Among patients hospitalized with COVID‐19 receiving intermediate‐ or therapeutic‐intensity anticoagulation, a major bleeding event occurred in 5.7%. Use of therapeutic‐intensity anticoagulation, critical illness, and elevated D‐dimer or ferritin levels at admission were associated with increased risk for major bleeding.

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JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range of content in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new forms of scholarship. For more information about JSTOR, please contact support@jstor.org. This is the second preliminary report of excavations and analyses of Opovo-Ugar Bajbuk, a Neolithic settlement of the Vinta-Plocnik culture located in the lowerTamis' river valley, NE Yugoslavia. The Opovo Archaeological Project began in the summer of 1983; this report covers the 1985-1987 field seasons. Work at Opovo has continued to reveal more about the unusual reliance placed by the site's inhabitants on wild food resources, the apparent lack of long-term settlement occupation, and the social organization ofproduction and consumption. An unexpected find of the 1987 season was afragment of linen, the earliest direct evidence for textile production in European prehistory. Detailed examination of methods of house construction and house destruction--part of an effort to investigate the role of households at the site-led to the discovery of the first two-story dwelling ever encountered at a Vinia site. The site of Opovo-Ugar Bajbuk is providing new light on previously unknown dimensions of variation within the Vinia culture. This content downloaded from 202.28.191.34 on Thu, 31 Dec 2015 13:09:05 UTC All use subject to JSTOR Terms and Conditions continuity at Opovo. The discussion focuses on the construction and destruction of Opovo's houses and on the production and spatial patterning of food remains, pottery, stone tools, and other artifacts found at the site. All of this information contributes to our attempt to compare the dynamics of late Neolithic socioeconomic change north and south of the Danube. Almost from the outset, it was clear that there were important differences (as well as similarities) between Opovo, north of the Danube, and other late Neolithic settlements south of the Danube. As was reported earlier (Tringham, Brukner, and Voytek 1985), the formal characteristics and the technology used in the production of This content downloaded from 202.28.191.34 on Thu, 31 Dec 2015 13:09:05 UTC All use subject to JSTOR Terms and Conditions

Market liberalization has accelerated and strengthened the pressure of competitors in an open struggle for the retention of existing and favor of new clients. It is necessary to understand the importance and necessity of good business communication, because if business communication in the organization is at a higher level, then the relationship between the organization and its clients is at a higher level as well. Employees in the organization are the ones who represent it, so if the internal communication in the organization is at a higher level, then the quality of services provided to clients is also at a higher level. Effective communication between organizations and customers enables an organization to achieve its goal, which is that it is positioned in the market as a modern organization that provides quality and services of high level.