Growth manipulation of fish is an important task in aquatic biotechnology. The growth promoting effect of recombinant Pichia pastoris expressing tilapia growth hormone was demonstrated in red tilapia fry (Oreochromis sp.), which were immersed into water containing intact cells of the recombinant yeast. The weight increase of the treated group was 171% relative to the control group after 6 weeks.
Chelation therapy plays a prominent role in the clinical treatment of metal intoxication. In this paper the principal causes of metal toxicity are exposed, and the chemical and biomedical requisites of a chelating agent are sketched. The chelating agents currently in use for scavenging toxic metal ions from humans belong to few categories: those characterized by coordinating mercapto groups, by oxygen groups, poliaminocarboxylic acids, and dithiocarbamates. Considering that the complex formation equilibria have been studied for less than 50% of chelators in use, some reflections on the utility of stability constants are presented, together with an evaluation of ligands under the stability profile. The competition between endogenous and toxic target metal ions for the same chelating agent is furthermore examined. A thorough examination of stability constant databases has allowed to select, for each toxic metal, the ligands distinguished by the best pMe values. Even though this selection does not consider the biomedical requisites of a chelating agent, it gives a clear picture both of the pMe values that can be attained, and of the most appropriate chelators for each metal ion.
Coordinatively unsaturated P-substituted dithiophosphonato, dithiophosphato, and dithiophosphito com-(3), and [Ni((Ph) 2 PS 2 ) 2 ] (4)} were reacted with the bis-functional ligands 3,5-di-(4-pyridyl)-1,2,4-thiadiazole (L1) and 3,5-di-(3-pyridyl)-1,2,4-thiadiazole (L2) to give the coordination polymers (1-4·L1) ∞ , (3·L2) ∞ , and (4·L2·2C 7 H 8 ) ∞ and the discrete dimers (1-2·L2) 2 , all characterised by single crystal X-ray diffraction. A comparison of the structures shows that L1 can be exploited for the predictable assembly of undulating chains independent of the nature of the Ni II complex, while L2 allows for the existence of different supramolecular constructs ensuing from different ligand conformations deriving from the rotation of the pyridyl rings. − ; R = alkyl substituent] 3 to assemble coordination polymers in combination with a variety of polypyridyl donors, in 5620 | CrystEngComm, 2016, 18, 5620-5629 This journal is ‡ The 112th issue of Chem. Rev. (2012) and the 16th issue of Chem. Soc. Rev. (2014) were entirely devoted to the synthesis and applications of MOFs, showing how rapidly this branch of solid state materials chemistry is evolving.
The novel enantiopure spacer 2,2′-dimethoxy-1,1′-binaphthyl-3,3′-bis(4-pyridyl-amido) has been designed to prepare helical coordination polymers here investigated by means of experimental and theoretical data.
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