MicroRNA-29a signaling protected against glucocorticoid-induced disturbance of Wnt and Dkk-1 actions and improved osteoblast differentiation and mineral acquisition. Promotion of miR-29a signaling is an alternative strategy for alleviating glucocorticoid-induced bone deterioration.

With the proliferation of Web services, service engineers demand good automatic service composition algorithms that not only synthesize the correct work plans from thousands of services but also satisfy the quality requirements of the users. Our observation is that conventional approaches suffer from serious limitations in scalability and accuracy when addressing both requirements simultaneously. We have designed and implemented a tool QSynth to use QoS objectives of service requests as the search directives. This approach effectively prunes the search space and significantly improves the accuracy of the search results. Evaluations show that, compared to the state of the art, QSynth achieves superior scalability and accuracy with respect to a large variety of composition scenarios. Our design of QSynth won the performance championship of Web Services Challenge 2009.

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The growth model of a spherical crystal in the undercooled melt including the surface energy, interfacial kinetics and convective flow is established. The effect of the convective flow induced by a small far field flow on the evolution and morphological stability of the interface of the spherical crystal is studied. The interface shape of the spherical crystal, which is affected by the far field flow, and the dispersion relation of the growth rate of amplitude of the perturbed interface are derived. It is shown that the convection induced by the far field flow makes the interface of the growing spherical crystal further grow in the upstream direction of the far field flow and inhibit growth in the downstream direction; the interface of the decaying spherical crystal further decays in the upstream direction and inhibits decay in the downstream direction. The theoretical result suggests that both the growth of the sphere in the upstream direction and the decay of the sphere in the downstream direction make the spherical crystal tend to evolve into an oval; the morphological stability of the interface depends on a certain radius R c such that the spherical crystal is unstable when its radius is greater than R c and stable when its radius is less than R c . The surface energy and interfacial kinetics have strong stabilizing effects on the growth of the spherical crystal. In the meantime interfacial kinetics is a stable factor of the interface when the interface of the sphere is growing; it is an unstable factor of the interface when the interface is decaying.solid-liquid interface, spherical crystal, convective flow, crystal growth, morphological stability Convective flow in melt has significant effect on the morphological stability of the curved solid-liquid interface in solidification. Huang and Glacksman [1] first observed the effect of buoyancy-driven convention on dendritic growth in the micro-gravity experiment. Buchholz and

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