The discrete movement task employed in this study consisted of moving a cursor from the center of a computer display screen to circular targets located 24.4 and 110.9 mm in eight radial directions. The target diameters were 2.7, 8.1, and 24.2 mm. Performance measures included movement time, cursor path distance, and root-mean-square cursor deviation. Ten subjects with no movement disabilities were studied using a conventional mouse and a lightweight ultrasonic head-controlled computer input pointing device. Average movement time was 306 ms greater (63%) for the head-controlled pointer than for the mouse. The effect of direction on movement time for the mouse was relatively small compared with the head-controlled pointer, which was lowest at 90 and 270 deg, corresponding to head extension and head flexion, respectively. Average path distance and root mean square displacement was lowest at off-diagonal directions (0, 90, 180, and 270 deg). This methodology was also shown to be useful for evaluating performance using an alternative head-controlled input device for two subjects having cerebral palsy, and measured subtle performance improvements after providing a disabled subject with lateral torso support.

BackgroundCanine distemper (CD) is one of the most contagious and lethal viral diseases in dogs. Despite the widespread use of vaccines, the prevalence of the CD virus (CDV) has increased at an alarming rate in recent years. In this phylodynamic study, we investigated the spatiotemporal modes of dispersal, viral demographic trends, and effectiveness of vaccines for CDV. A total of 188 full-length CDV hemagglutinin (H) gene sequences dataset were subjected to recombination analysis, including seven from modified live vaccine (MLV) strains and 12 from Taiwan specimens. After excluding the MLV strains and potential recombinant strains, alignments of 176 of 188 previous CDV strains were further used to analyze phylodynamic characteristics, and evidence of selection, and co-evolution.ResultsThe CDV genotype consisted of MLV-associated genotypes such as America-1 and Rockborn-like strains, which were characterized by long terminal branches and no distinct geographical patterns among lineages. In contrast, wild-type isolates clustered into lineages with a spatiotemporal structure and short terminal branches. Co-circulation and extensive diversification were simultaneously observed. The sequence variation signature was shaped by both geographic diversity and host tropism. Codon 506 was identified as a multi-epistatic interacting in the H protein.ConclusionsThe topological signature revealed in this study suggests different epidemic scenarios. For example, a ladder-like backbone is a hallmark of directional selection, and cladogenesis at long terminal branches indicates the emergence of a surviving lineage. The stable effective viral population of CDV indicate the effectiveness of vaccines currently used to control the virus.Electronic supplementary materialThe online version of this article (doi:10.1186/s12917-015-0491-9) contains supplementary material, which is available to authorized users.

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The reduction of electromigration failure times with scaling presents a critical challenge for continued technology development. Electromigration failure is determined by void morphology and Cu drift velocity. Using observations of changes in these parameters, particularly the increase in drift velocity due to the increasingly polycrystalline Cu grain structure, we are able to accurately model trends in failure times between the 65 and 20 nm nodes. Below 20 nm failure times will continue to decrease, but at a faster rate at the low percentiles associated with circuit reliability. Metal capping to reduce interfacial diffusion of Cu has no impact on the drift velocity at the most advanced technology nodes. Control of Cu grain structure and development of electromigration resistant Cu alloys provide the most effective means of improving electromigration performance.