Serum pro-inflammatory cytokines may play an important role in the association between periodontal disease and hyperlipidaemia.

Systemic and local MDA levels are increased by smoking in addition to the impact of periodontitis. The decreased local SOD, GSH-Px, and CAT activities observed in periodontitis patients may increase with smoking.

Improved periodontal health may influence metabolic control of hyperlipidemia and could be considered as an adjunct to the standard measures of hyperlipidemic patient care.

NSPT decreased oxidative stress and the inflammatory status of patients with MetS and chronic periodontitis. Although similar periodontal improvements were achieved in both groups, the decreases in levels of hs-CRP and IL-6 in the MetS group did not reach the levels in the SH group. Based on these results, NSPT could be more effective in the control of systemic inflammation in patients with MetS in the short-term.

The IL-11/IL-17 ratio was decreased in the GAgP group because of the decreased IL-11 levels. The IL-11/IL-17 axis and the link between IL-17 and neutrophil function disorders in AgP should be investigated to clarify the role of the IL-11/IL-17 axis and its balance and imbalance in the pathogenesis of AgP.

Serum Lp-PLA(2) and hsCRP levels may play an important role in the association between periodontal disease and hyperlipidemia, and the control of these mediators may affect the inflammatory control of patients with hyperlipidemia and periodontal disease.

Objectives:The aim of this study was to compare the demographic and clinical features of tooth sensitivity (TS) in subjects with and without fluorosis.Methods:A total of 2249 subjects (378 subjects with fluorosis and 1871 subjects without fluorosis) were examined for TS during a study period of one year and TS was determined in 122 subjects. The level of TS was evaluated on a visual analogue scale (VAS). The sensitivity evaluation was made by applying tactile and cold air stimuli. In teeth sensitive to any stimuli, the plaque index (PI), gingival index (GI), gingival recession (GR) and periodontal pocket depth (PPD) were recorded. Fluorosis was assessed using the Dean Index.Results:One hundred and twenty-two participants were found to have TS (5.42%). The frequency of TS in subjects with fluorosis was 9.26%, while the frequency of TS in subjects without fluorosis was 4.65%. There was a statistically significant difference between the groups in terms of TS frequency (P=0.0003). In contrast, there were no significant differences between the groups for periodontal parameters except PI.Conclusions:The results of the study showed that the subjects with fluorosis may have been suffering from TS more than the subjects with normal dentition. Further studies are necessary to determine the factors that contribute to sensitivity of teeth with fluorosis.

The purpose of the present study was to evaluate periodontal health status in children with sickle cell disease (SCD). Forty-nine children with SCD and 39 systemically healthy sex- and age-matched children were enrolled in the study. Plaque index, gingival index, bleeding on probing, pocket depth, salivary volume, and hyperplastic index were recorded. In addition, the histopathological evaluation of gingiva was made in a child with SCD. There were significant differences between the groups with regard to hyperplastic index (P < 0.05), whereas there were no differences in other parameters. Gingival enlargement was detected in 27 children (55.1%) in the SCD group and 6 children (15.4%) in the control group (P < 0.001). However, there were no differences in periodontal health status of children in the SCD and control groups, the most important finding of this study that the gingival enlargement was more prevalent in children with SCD. Sickling and chronic inflammation seen in SCD may affect gingival tissues. Therefore, physicians and dentists must be aware of the effects of SCD on gingival tissues.