No abstract

Non-canonical, four-stranded nucleic acids secondary structures are present within regulatory regions in the human genome and transcriptome. To date, these quadruplex structures include both DNA and RNA G-quadruplexes, formed in guanine-rich sequences, and i-Motifs, found in cytosine-rich sequences, as their counterparts. Quadruplexes have been extensively associated with cancer, playing an important role in telomere maintenance and control of genetic expression of several oncogenes and tumor suppressors. Therefore, quadruplex structures are considered attractive molecular targets for cancer therapeutics with novel mechanisms of action. In this review, we provide a general overview about recent research on the implications of quadruplex structures in cancer, firstly gathering together DNA G-quadruplexes, RNA G-quadruplexes as well as DNA i-Motifs.

Soil health is a term used to describe the general state or quality of soil, and in an agroecosystem, soil health can be defined as the ability of the soil to respond to agricultural practices in a way that sustainably supports both agricultural production and the provision of other ecosystem services. Conventional agricultural practices cause deterioration in soil quality, increasing its compaction, water erosion, and salinization and decreasing soil organic matter, nutrient content, and soil biodiversity, which negatively influences the productivity and long-term sustainability of the soil. Currently, there are many evidences throughout the world that demonstrate the capability of conservation agriculture (CA) as a sustainable system to overcome these adverse effects on soil health, to avoid soil degradation and to ensure food security. CA has multiple beneficial effects on the physical, chemical, and biological properties of soil. In addition, CA can reduce the negative impacts of conventional agricultural practices on soil health while conserving the production and provision of soil ecosystem services. Today, agricultural development is facing unprecedented challenges, and CA plays a significant role in the sustainability of intensive agriculture. This review will discuss the impact of conservation agricultural practices on soil health and their role in agricultural sustainability.