SUMMARY BackgroundAn impairment of cellular immune response may contribute to the persistency of hepatitis C virus infection.

In a real clinical practice setting with a high proportion of patients with advanced fibrosis, effectiveness of first-generation PIs was high except for NR patients, with similar SVR rates being achieved by BOC and TVR.

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RESUMEN En el presente trabajo se hace un estudio sobre la evolución de los manuales escolares utilizados en España desde 1939 hasta 1959. De esta manera, se muestra como dichos manuales sirvieron para inculcar la ideología que quería consolidar el régimen de Franco. Además, para contribuir con el estudio de los manuales escolares, se analizan cinco manuales editados y publicados en Navarra durante estos años, lo que permite ver como en ellos se siguieron los mismos pasos que se estaban dando en el panorama nacional. LABURPENA Lan honetan, Espainian 1939tik 1959.era erabilitako eskola eskuliburuen bilakaerari buruzko azterketa bat egiten da. Modu honetan, eskuliburu hauek erregimen frankistak sendotu nahi zuen ideologia nola piztu zen erakusten da. Horrez gain, eskuliburuak aztertzen laguntzeko, urte hauetan Nafarroan editatu eta argitaratutako bost eskuliburu aztertzen dira, eta horri esker, eszena nazionalean ematen ari ziren urrats berak nola jarraitu ziren ikus daiteke. ABSTRACT This work studies the evolution of the school textbooks used in Spain from 1939 to 1959. In this way, it shows how these textbooks served to instil the ideology that Franco’s regime wished to consolidate. Furthermore, to contribute to the study of the school textbooks, an analysis was made of five textbooks edited and published in Navarra in this same period, making it possible to see how Navarra was following the same steps that were being taken on the national scene.

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de 3 a 5 mg/kg/dosis, según el esquema, a las 0, 2, 6 y 8 semanas. Infliximab resultó eficaz y seguro para el tratamiento de escleritis asociada a AR y vasculitis ANCA MPO positivo, refractaria a tratamiento con DARMES y corticoides en dosis altas. Los injertos de tejido esclerocorneal evolucionaron favorablemente con infliximab. Palabras clave: Escleritis, infliximab, vasculitis ANCA positivo, artritis reumatoide. AbstractExperience with infliximab (monoclonal antibody with strong anti-inflammatory action) for treatment of ocular inflammatory disease secondary to rheumatic diseases and refractory to disease-modifying antirheumatic drugs (DMARDs) is described. We evaluated the cases of a 50 year-old patient with active rheumatoid arthritis (RA) and a 37 year-old patient with myeloperoxidase antineutrophil cytoplasmic vasculitis antibody (MPO ANCA) without noble organ affectation, both with bilateral scleritis and left eye corneal perforation with iris prolapse. They received infliximab 3-5 mg/kg IV at 0, 2, 6, and 8 weeks. Infliximab was effective and safe for treatment of scleritis associated to RA and MPO ANCA positive vasculitis refractory to treatment with both DMARDs and high dose corticosteroids. Corneoscleral tissue grafts developed favorably with infliximab.