In an analysis of data from 2 phase 3 clinical trials of patients with chronic HCV infection of any genotype, we found the combination of sofosbuvir, velpatasvir, with or without voxilaprevir, to increase PRO scores compared with placebo. These findings indicate the comprehensive benefit of these regimens during treatment and after SVR.

Quantification of human impact on water, sediment, and nutrient fluxes at the global scale demands characterization of reservoirs with an accuracy that is presently unavailable. This letter presents a new method, based on virtual dam placement, to make accurate estimations of area‐volume relationships of large reservoirs, using solely readily available elevation data. The new method is based on regional similarity of area‐volume relationships. The essence of the method is that virtual reservoirs are created in the vicinity of an existing reservoir to derive area‐volume relationships for the existing reservoir. The derived area‐volume relationships reproduced in situ bathymetric data well. An intercomparison for twelve reservoirs resulted in an average R2 = 0.93. This is a significant improvement on estimates using the best existing global regression model, which gives R2 = 0.54 for the same set of reservoirs.

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Appendix 1. Matrix of study station and index station pairings for both daily value regressions for streamflow statistic adjustment and two-station adjustment for flood frequency analysis ……………………………………………………………… Appendix 2. SWRCB and USGS hydrographs of mean daily flows for all stations with estimates provided by SWRCB ………………………………………………… Appendix 3. Computed relative standard errors plotted versus basin characteristics for all stations' 25-and 50-percentile December 15 to March 31 mean-daily-flow estimates …………………………………………………………………………

H. pylori VacA inhibits PGE2-stimulated duodenal epithelial HCO3- secretion by a histamine-dependent mechanism. This effect likely contributes to the damaging effect of H. pylori in the duodenal mucosa.