The present work demonstrates the synthesis and biological properties of novel manganese sulphide (MnS) hydrogels using acacia Senegal gum (ASG) as a natural biopolymer and divinyl sulfone (DS) as a cross-linker via in situ reduction method. Acacia Senegal Gum hydrogel p(ASG) and manganese sulphide (MnS) nano-rods fabricated hydrogels p(ASG)-MnS hydrogels were then characterized through various techniques such as scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-Ray diffraction (XRD), fourier transform infrared (FTIR) spectroscopy, and thermogravimetric analysis (TGA). Biomedical investigation of pristine and p(ASG)-MnS was carried out by evaluating their biocompatibility, antioxidant and antidiabetic activities. Both the pristine and hybrid hydrogel shown excellent biocompatibility with 0.759 % hemolysis for p(ASG) and 2.386 % haemolytic activity for p(ASG)-MnS at the highest tested dose of 400 µg/mL. Furthermore, p (ASG)-MnS displayed remarkable antioxidant activities as evaluated by multiple antioxidant assays. The p(ASG)-MnS exhibit better DPPH and ABTS scavenging activities of 66.91±0.22 (%) and 98.40±0.58 (TEAC), respectively. On the other hand, p (ASG) showed 7.5%±0.58 (%) FRSA and 4.40±0.28 (TEAC), activity. Similarly, total antioxidant capacity (TAC) and total reducing power (TRP) values for p (ASG)-MnS were 184.32±2.3 (µg AAE/mg) and 179.83±0.1.2 (µg AAE/mg), respectively thus proving the considerable antioxidant properties of the hybrid hydrogels. The antidiabetic activity of p (ASG) and p(ASG)-MnS hydrogels were examined by determining their alpha-amylase inhibition potential. The p(ASG)-MnS displayed average alpha-amylase with numerical value 16.7±1.4 (%) as compared to p(ASG) with very weak inhibition potential of 4.18±0.98 (%). To conclude, p(ASG)-MnS hydrogel have excellent biocompatibility and antioxidant potential and reasonable antidiabetic activity as compare to pristine p(ASG).
The global demand for renewable energy as an alternative to traditional fossil fuels has motivated the scientific community to develop highly efficient nanocomposite materials that can be used for enhancement to optoelectronic technology. In the present work, organometallics Alq3 and Alq3/CNTs were prepared by cost-effective chemical route. X-ray diffraction (XRD) and scanning electron microscopy (SEM) were performed to identify the structural and morphological features. The hybrid Alq3/CNTs exhibited polycrystalline structure with a large surface area. The optical band gap (E_g) of Alq3 film was evaluated within the visible spectrum in the range of 3.047 eV which reduced to 2.979 eV by CNTs integration. Ag/Alq3/p-Si/Al and Ag/Alq3/CNTs/p-Si/Al photodiodes were fabricated using thermal evaporating technique. Current-voltage (I-V) and capacitance/conductance-voltage (C/G-V) were measured to analyze the photodiode behavior. The main electronic parameters like R_s,n,ϕ_b 〖and I〗_o were determined using different models indicating that the composite photodiode of high performance in which R_s was decreased whereas N_a was increased with doping. Besides, the photocurrent sensitivity was increased from 1.45×〖10〗^(-8) A to 1.1 ×〖10〗^(-5) A due to increase of free charge carriers.
: Nanotechnology studies the various phenomena of physio-chemical procedures and biological properties for the generation of nanosized particles, and their rising challenges in the various sectors, like medicine, engineering, agriculture, electronic, and environmental studies. The nanosized particles exhibit good anti-microbial, anti-inflammatory, cytotoxic, drug delivery, anti-parasitic, anti-coagulant and catalytic properties because of their unique dimensions with large surface area, chemical stability and higher binding density for the accumulation of various bio-constituents on their surfaces. Biological approaches for the synthesis of silver nanoparticles (AgNPs) have been reviewed because it is an easy and single-step protocol and a viable substitute for the synthetic chemical-based procedures. Physical and chemical approaches for the production of AgNPs are also mentioned herein. Biological synthesis has drawn attention because it is cost-effective, faster, non-pathogenic, environment-friendly, easy to scale-up for large-scale synthesis, and having no demand for usage of high pressure, energy, temperature, or noxious chemical ingredients, and safe for human therapeutic use. Therefore, the collaboration of nanomaterials with bio-green approaches could extend the utilization of biological and cytological properties compatible with AgNPs. In this perspective, there is an immediate need to develop ecofriendly and biocompatible techniques, which strengthen efficacy against microbes and minimize toxicity for human cells. The present study introduces the biological synthesis of silver nanoparticles, and their potential biomedical applications have also been reviewed.
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