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Adıyaman Üniversitesi Eğitim ve Araştırma Hastanesi, yoğun bakım ünitesinde beyin ölümü tanısı konulan olguların demografik ve klinik özellikleri retrospektif olarak incelenerek, organ bağışı kabul oranları sunuldu. Gereç ve Yöntem: Hastanemiz yoğun bakım ünitesinde 2008-2014 yılları arasında beyin ölümü tanısı konmuş hastalar retrospektif olarak incelendi. Tüm hastalar; yaş, cinsiyet, beyin ölümü nedeni, kan grubu, organ bağışı kabul ve red nedenleri, kardiyak arrest geçirme ve vazopressin kullanma durumu, laboratuvar testleri, apne testi öncesi ve sonrası kan gazı değerleri, yoğun bakımda izlem süresi, apne testi, yıl ve mevsimsel dağılım açısından değerlendirildi. Donör adayı olan olgular verilen organ ve alıcı olan hastalar demografik özelliklerine göre ayrıca değerlendirildi. Bulgular: Otuz dört (%59,6) erkek, 23 (%40,4) kadın toplam 57 hastaya beyin ölümü tanısı konuldu. En sık nedenler travmatik subaraknoid kanama (SAK) ve intraserebral hematom idi. Olguların çoğu A Rh (+) kan grubunda (n=18, %31,5) idi. Rh (+) hastalarda Rh (-) hastalara oranla 4,7 kat fazla beyin ölümü tespit edildi. Kardiyak arrest görülme oranı %12,3 (n=7) olup en sık SUMMARY Objective: It was aimed to present the acceptance rate of organ donation of cases that were diagnosed with brain death and evaluated in terms of their demographic and clinical properties retrospectively in Adıyaman University Training and Research Hospital. Material and Method: In the intensive care unit of our hospital, cases that were diagnosed with brain death between the dates of January 2008 and December 2014 were retrospectively analyzed. Cases were evaluated in terms of age, sex, cause of brain death, blood groups, donation status, reasons for acceptance or rejection of donation, cardiac arrest, vasopressin treatment, laboratory test results, arterial blood gas values before and after the apnea test, intensive care unit follow-up durations, apnea test, seasonal and annual distribution. Also, potential donors and recipients were analyzed in accordance with their demographic characteristics. Results: The diagnosis of brain death was made in totally 57 cases; of those, 34 (59.6%) were men and 23 (40.4%) were women. The most common causes for brain death were traumatic subarachnoid hemorrhage (SAH) and intracerebral hematoma. Most of the cases had A Rh+ blood type (n=18, 31.5%) and the rate of brain death was 4.7 times higher in Rh (+) patients in comparison to Rh (-) patients. The rate of incidence of cardiac arrest was 12.3% (n=7), and it was more common in traumatic SAH patients. The rate of receiving vasopressor therapy was 21.1% (n=12), and the mean duration of therapy was 1.3±0.8 days. It was more commonly used in traumatic SAH patients (n=10). The follow-up period was 2.7±3.2 (minimum: 1, maximum: 17) days. Five patients were considered to be organ donors. The most common reason for acceptance of donation was the effect of organ transplantation coordinator during family interviews (n=3, 60%). In total, 4 livers, 5 kidneys and 1 heart transplantation oper...

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The present study was designed to determine the possible hepatoprotective effects of Salvia cryptantha (black weed) plant extract against carbon tetrachloride (CCl4)-induced hepatic injury in rats. Animals were grouped as follows: control group (Group I), CCl4 group (Group II), olive oil group (Group III), CCl4 + S. cryphantha 200 mg/kg group (Group IV), and CCl4 + S. cryptantha 400mg/kg group (Group V). Rats were injected intraperitoneally with CCl4 diluted in olive oil (50% v/v) at a dose of 1ml/kg body weight.  Bax and Caspase3 were determined by immunohistochemical staining, while apoptotic index was evaluated using TUNEL assay. Total mRNA was isolated from liver tissues, and the levels of BCL2, Caspase3, SOD, CAT, and glutathione peroxidase (GPx) were determined by using PCR, while MDA level were determined using a colorimetric assay. The antioxidant and anti-apoptotic gene transcripts were decreased in all of the control and treatment groups, while Caspase3 levels were not statistically different. The S. cryptantha plant extract treatment was also found to improve SOD, GPx, and catalase levels, while reducing the serum levels of MDA. The extract of S. cryptantha supplementation had a protective effect against CCl4-induced liver damage. S. cryptantha extract as a supplement may be useful as a hepato-protective agent to combat the toxic effects caused by CCl4 and other chemicals.

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