Due to its potential for multi-gigabit and low latency wireless links, millimeter wave (mmWave) technology is expected to play a central role in 5th generation (5G) cellular systems. While there has been considerable progress in understanding the mmWave physical layer, innovations will be required at all layers of the protocol stack, in both the access and the core network. Discrete-event network simulation is essential for end-to-end, cross-layer research and development. This paper provides a tutorial on a recently developed full-stack mmWave module integrated into the widely used open-source ns-3 simulator. The module includes a number of detailed statistical channel models as well as the ability to incorporate real measurements or raytracing data. The Physical (PHY) and Medium Access Control (MAC) layers are modular and highly customizable, making it easy to integrate algorithms or compare Orthogonal Frequency Division Multiplexing (OFDM) numerologies, for example. The module is interfaced with the core network of the ns-3 Long Term Evolution (LTE) module for full-stack simulations of end-to-end connectivity, and advanced architectural features, such as dualconnectivity, are also available. To facilitate the understanding of the module, and verify its correct functioning, we provide several examples that show the performance of the custom mmWave stack as well as custom congestion control algorithms designed specifically for efficient utilization of the mmWave channel.This work has been submitted to IEEE Communication Surveys and Tutorials for possible publication.

The vast available spectrum in the millimeter wave (mmWave) bands offers the possibility of multi-Gbps data rates for fifth generation (5G) cellular networks. However, mmWave capacity can be highly intermittent due to the vulnerability of mmWave signals to blockages and delays in directional searching. Such highly variable links present unique challenges for adaptive control mechanisms in transport layer protocols and end-to-end applications. This paper considers the fundamental question of whether TCP -the most widely used transport protocol -will work in mmWave cellular systems. The paper provides a comprehensive simulation study of TCP considering various factors such as the congestion control algorithm, including the recently proposed TCP BBR, edge vs. remote servers, handover and multiconnectivity, TCP packet size and 3GPP-stack parameters. We show that the performance of TCP on mmWave links is highly dependent on different combinations of these parameters, and identify the open challenges in this area.

Abstract-The IMT 2020 requirements of 20 Gbps peak data rate and 1 millisecond latency present significant engineering challenges for the design of 5G cellular systems. Use of the millimeter wave (mmWave) bands above 10 GHz -where vast quantities of spectrum are available -is a promising 5G candidate that may be able to rise to the occasion.However, while the mmWave bands can support massive peak data rates, delivering these data rates on end-to-end service while maintaining reliability and ultra-low latency performance will require rethinking all layers of the protocol stack. This papers surveys some of the challenges and possible solutions for delivering end-to-end, reliable, ultra-low latency services in mmWave cellular systems in terms of the Medium Access Control (MAC) layer, congestion control and core network architecture.

The millimeter wave (mmWave) bands are likely to play a significant role in next generation cellular systems due to the possibility of very high throughput thanks to the availability of massive bandwidth and high-dimensional antennas. Especially in Non-Line-of-Sight conditions, significant variations in the received RF power can occur as a result of the scattering from nearby building and terrain surfaces. Scattering objects come and go as the user moves through the local environment. At the higher end of the mmWave band, rough surface scatter generates cluster-based small-scale fading, where signal levels can vary by more than 20 dB over just a few wavelengths. This high level of channel variability may present significant challenges for congestion control. Using our recently developed end-to-end mmWave ns3-based framework, this paper presents the first performance evaluation of TCP congestion control in next-generation mmWave networks. Importantly, the framework can incorporate detailed models of the mmWave channel, beamforming and tracking algorithms, and builds on statistical channel models derived from real measurements in New York City, as well as detailed ray traces.

The increasing demand of data, along with the spectrum scarcity, are motivating a urgent shift towards exploiting new bands. This is the main reason behind identifying mmWaves as the key disruptive enabling technology for 5G cellular networks. Indeed, utilizing new bands means facing new challenges; in this context, they are mainly related to the radio propagation, which is shorter in range and more sensitive to obstacles. The resulting key aspects that need to be taken into account when designing mmWave cellular systems are directionality and link intermittency. The lack of network level results motivated this work, which aims at providing the first of a kind open source mmWave framework, based on the network simulator ns-3. The main focus of this work is the modeling of customizable channel, physical (PHY) and medium access control (MAC) layers for mmWave systems. The overall design and architecture of the model are discussed in details. Finally, the validity of our proposed framework is corroborated through the simulation of a simple scenario.

The millimeter-wave (mmWave) frequencies have attracted considerable attention for fifth generation (5G) cellular communication as they offer orders of magnitude greater bandwidth than current cellular systems. However, the medium access control (MAC) layer may need to be significantly redesigned to support the highly directional transmissions, ultra-low latencies and high peak rates expected in mmWave communication. To address these challenges, we present a novel mmWave MAC layer frame structure with a number of enhancements including flexible, highly granular transmission times, dynamic control signal locations, extended messaging and ability to efficiently multiplex directional control signals.Analytic formulae are derived for the utilization and control overhead as a function of control periodicity, number of users, traffic statistics, signal-to-noise ratio and antenna gains. Importantly, the analysis can incorporate various front-end MIMO capability assumptions -a critical feature of mmWave. Under realistic system and traffic assumptions, the analysis reveals that the proposed flexible frame structure design offers significant benefits over designs with fixed frame structures similar to current 4G long-term evolution (LTE). It is also shown that fully digital beamforming architectures offer significantly lower overhead compared to analog and hybrid beamforming under equivalent power budgets. 5G cellular systems, millimeter wave, frame structure, radio resource utilization, control overhead. Index Terms

BackgroundBlood-based gene expression or epigenetic biomarkers of Parkinson’s disease (PD) are highly desirable. However, accuracy and specificity need to be improved, and methods for the integration of gene expression with epigenetic data need to be developed in order to make this feasible.MethodsWhole blood gene expression data and DNA methylation data were downloaded from Gene Expression Omnibus (GEO) database. A linear model was used to identify significantly differentially expressed genes (DEGs) and differentially methylated genes (DMGs) according to specific gene regions 5′—C—phosphate—G—3′ (CpGs) or all gene regions CpGs in PD. Gene set enrichment analysis was then applied to DEGs and DMGs. Subsequently, data integration analysis was performed to identify robust PD-associated blood biomarkers. Finally, the random forest algorithm and a leave-one-out cross validation method were performed to construct classifiers based on gene expression data integrated with methylation data.ResultsEighty-five (85) significantly hypo-methylated and upregulated genes in PD patients compared to healthy controls were identified. The dominant hypo-methylated regions of these genes were significantly different. Some genes had a single dominant hypo-methylated region, while others had multiple dominant hypo-methylated regions. One gene expression classifier and two gene methylation classifiers based on all or dominant methylation-altered region CpGs were constructed. All have a good prediction power for PD.ConclusionsGene expression and methylation data integration analysis identified a blood-based 53-gene signature, which could be applied as a biomarker for PD.Electronic supplementary materialThe online version of this article (10.1186/s13148-019-0621-5) contains supplementary material, which is available to authorized users.

The growing demand for ubiquitous mobile data services along with the scarcity of spectrum in the sub-6 GHz bands has given rise to the recent interest in developing wireless systems that can exploit the large amount of spectrum available in the millimeter wave (mmWave) frequency range. Due to its potential for multi-gigabit and ultra-low latency links, mmWave technology is expected to play a central role in 5th Generation (5G) cellular networks. Overcoming the poor radio propagation and sensitivity to blockages at higher frequencies presents major challenges, which is why much of the current research is focused at the physical layer. However, innovations will be required at all layers of the protocol stack to effectively utilize the large air link capacity and provide the end-to-end performance required by future networks.Discrete-event network simulation will be an invaluable tool for researchers to evaluate novel 5G protocols and systems from an end-to-end perspective. In this work, we present the first-of-its-kind, open-source framework for modeling mmWave cellular networks in the ns-3 simulator. Channel models are provided along with a configurable physical and MAC-layer implementation, which can be interfaced with the higher-layer protocols and core network model from the ns-3 LTE module to simulate end-to-end connectivity. The framework is demonstrated through several example simulations showing the performance of our custom mmWave stack.