BackgroundPlatelet-rich plasma (PRP) is an autologous concentration of human platelets contained in a small volume of plasma and has recently been shown to accelerate rejuvenate aging skin by various growth factors and cell adhesion molecules.ObjectiveThis study was conducted to evaluate the efficacy and safety of intradermal injection of PRP in the human facial rejuvenation.MethodsThis study was a prospective, single-center, single-dose, open-label, non-randomized controlled clinical study. PRP injected to the upper site of this right infra-auricular area and all face. Saline was injected to the left infra-auricular area. Histopathological examinations were performed before PRP treatment, 28 days after the PRP, and saline (control) treatments.ResultsTwenty women ranging in age from 40 to 49 years (mean age, 43.65±2.43 years) were enrolled in the study. The mean optical densities (MODs) of collagen in the pre-treatment, control, and PRP-treated area were measured. They were 539±93.2, 787±134.15, 1,019±178, respectively. In the MOD of PRP, 89.05 percent improvement was found when MOD of PRP was compared with MOD of pre-treatment. The mean MOD of collagen fibers was clearly highest on the PRP side (p<0.001). The PRP-to-saline improvement ratio (89.05% to 46.01%) was 1.93:1. No serious side effects were detected.ConclusionPRP increases dermal collagen levels not only by growth factors, but also by skin needling (the mesotherapy technique 'point by point'). PRP application could be considered as an effective (even a single application) and safety procedure for facial skin rejuvenation.

It appears that certain skin diseases acne, fungal infections, contact dermatitis and urticarial cause serious health problems. Public health policies should be implemented in order to manage these problems rationally.

Hyperbaric oxygen therapy (HBOT) appears to enhance wound healing, increase bactericidal activity, and act synergistically with a number of antibiotics. The aim of this study was to evaluate the efficacy of HBOT as an adjunctive therapy in patients with hidradenitis suppurativa (HS) treated with a combination of systemic rifampicin and clindamycin. The study was a prospective, single-center, single-dose, open-label, randomized controlled clinical study of HBOT in patients with moderate to severe HS. Efficacy was measured by modified Sartorius score (SS), HS Severity Index (HSSI), Dermatology Life Quality Index (DLQI), and a visual analog scale (VAS) before treatment and after the completion of 4 and 10 weeks of treatment. Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels were also measured. Forty-three patients were enrolled in the study. More patients in the HBOT than in the control group showed a decrease of ≥50% from baseline parameters at week 10 for SS (100%), HSSI (100%), DLQI (95.5%), VAS (100%), ESR (100%), and CRP (72.7%). Clinically and statistically significant improvements from baseline were observed at 4 and 10 weeks in HSSI (P = 0.009 at both), SS (P = 0.021 at both), and DLQI (P = 0.044 at week 4, P = 0.009 at week 10). Adjunctive HBOT was considered to be effective in significantly improving antibiotic treatment of HS. The treatment was well tolerated, and no unexpected safety issues were identified.

Amaç: Teledermatoloji, dermatolojik bilgilerin telekomünikasyon teknolojileri kullanılarak uzak mesafelere iletilmesidir. Bu çalışmada, ülkemizde dermatologların teledermatoloji hakkındaki bilgi düzeyini, günlük klinik pratiklerinde kullandıkları teledermatoloji yöntemlerini ve teledermatoloji ünitelerinin kurulması durumunda sergileyecekleri yaklaşımları değerlendirmeyi amaçladık. Yöntem: Tanımlayıcı kesitsel olarak planlanan bu çalışmada, 15 sorudan oluşan anket elektronik posta ile dermatologlara iletildi. Sekiz haftalık bir süre içerisinde tam ve hatasız doldurularak geri gönderilen anketler çalışmaya dahil edildi. Bulgular: Yüz on altı anketin değerlendirmeye alındığı çalışmada, katılımcıların %37.9'unun üniversite, %28'inin eğitim ve araştırma, %27'sinin devlet, %18.1'inin de özel hastanelerde çalıştığı gözlendi. Öte yandan katılımcıların %94'ünün, çalıştıkları kliniklerde teledermatoloji ünitesinin olmadığı, %50'sinin teledermatoloji hakkında az, %25.9'unun ise orta düzeyde bilgi sahibi olduğu saptandı. En sık (%43.10; 50/116) kullanılan teledermatolojik yöntemin dermatologlara elektronik posta yoluyla hasta resmi gönderilerek ("depola ve gönder") "danışma" şeklinde yapıldığı öğrenildi. Teledermatolojinin ülkemizde resmi olarak kurulup uygulanmasını dermatologların %55.2'si "çok fazla", %30.2'si ise "fazla" istediğini belirtti. Sonuç: Bu çalışmayla, birçok meslektaşımızın teledermatoloji konusundaki bilgileri sınırlı olmasına karşın, birçoğunun mesleklerini icra ederken teledermatolojiyi kullanabildikleri ve ülkemizde resmi olarak uygulamaya konmasına sıcak baktıkları ortaya konulmuştur. Anahtar kelimeler: Depola ve gönder yöntemi, teledermatoloji, canlı video-konferans yöntemi

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