We aimed to answer the following three questions in this study: (1) Does tranexamic acid (TA) reduce the amount of bleeding in total knee arthroplasty (TKA)? (2) Does TA reduce requirement for blood transfusion? (3) Is there any difference on reliability and efficacy between topical and intravenous (IV) applications of TA? Patients were allocated into three groups randomly by a software program as topical, IV, and control group. TA was applied as 20 mg/kg to the IV group and as 3 g/100 mL saline to the topical group. The hemoglobin values were recorded preoperatively and postoperatively on the same day and on day 1 and day 2. Removal of the drain postoperatively and length of hospital stay, as well as any complications such as pulmonary embolism or deep venous thrombosis, were also noted. The study comprised 40 patients in the IV group, 42 in the topical group, and 41 in the control group. The drain output values were similar in the IV and topical groups ( = 0.161), while those of the control group were significantly higher than both the IV and topical groups ( < 0.001 and < 0.001). Transfusion was applied to 19.5% of cases in the control group, 4.8% in the topical group, and 5.1% of the IV group ( = 6.522; = 0.038). The results of the study showed that 20 mg/kg single-dose IV bolus or 3 g topical TA application reduced blood loss and transfusion requirement without increasing the rate of thromboembolic complications in unilateral primary TKA.
A functional and stable shoulder can be obtained with glenoid augmentation in patients with chronic locked posterior shoulder dislocation. When other treatment alternatives are considered for a young patient group, this is a safe and applicable treatment method.
Introduction: Osteoarthritis (OA), the most common degenerative joint disorder, affects the quality of lives (QoL) of the sufferers as other chronic disorders. Therefore assessment of QOL is of particular importance. In this study we aimed to evaluate the quality of life (QoL) in patients with knee osteoarthritis by using the Nottingham Health Profile (NHP) and to determine its relationships with disability and pain indices.
Methods:Patients with knee OA (n=105), with a mean age of 59.79±10.10 yrs and 50 sex and age-matched healthy controls were included in the study. Age, sex, symptom durations, body mass index (BMI) and Kellgren-Lawrence scores were recorded. NHP was used in assessment of QoL in all patients and controls. Knee injury and Osteoarthritis Outcome Score (KOOS) was used in assessment of disability and pain was assessed by using Visual Analog Scale (VAS) in patients.Results: Patients with knee OA had higher scores in all subgroups of NHP than controls. In patients the NHP total score significantly correlated to presence of effusion, VAS pain and the KOOS subgroups scores.
Discussion And Conclusion:The patients with knee OA had a significantly poorer quality of life compared to the healthy persons. Besides, NHP was found to be associated with clinical examination findings and disability. We assume that NHP can effectively be used in evaluation of health status in patients with knee OA.
Keywords:The Knee injury and Osteoarthritis Outcome Score, Nottingham Health Profile, knee osteoarthritis. Received: 25.12.2015 Accepted: 18.01.2016 Abstract Introduction
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