Quality of Life in Knee Osteoarthritis; Correlation with Clinical Measures and the Knee Injury and Osteoarthritis Outcome Score

Aksekili, Mehmet Atıf Erol; Fidan, Fatma; Alkan, Berat Meryem; Alemdar, Ayşenur; Aksekili, Hatice; Ardıçoğlu, Özge

doi:10.5505/actamedica.2016.41636

Cited by 6 publications

(8 citation statements)

References 22 publications

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“…A study by Kim et al [19], which included 504 patients showed that subjects with knee pain compared to those without knee pain, even after adjusting for age, sex and the presence of knee OA, had worse scores in all of the WOMAC and SF-12 subscales. Thus, the present study has confirmed the results of previous studies, in which knee pain was associated with worse quality of life [7,19,33] and worse physical functioning [19,33]. Kawano et al [17] analyzed life quality in patients with knee OA and concluded that their perception of life quality was low, particularly in the domains of functional capacity, functional limitations and pain measured by the SF-36 questionnaire.…”

Section: Discussionsupporting

confidence: 90%

“…The assessment should not be focused solely on the diseased organ or organ system, but must also include functional disorders (physical, emotional, social) which patients may experience as a result of their illness. Instruments for measuring the quality of life are intended to evaluate the changes in patients' health status in a given period of time and to evaluate the effects of the applied therapy [7].…”

Section: Introductionmentioning

confidence: 99%

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The impact of pain on functionality and health related quality of life in patients with knee osteoarthritis

et al. 2019

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Introduction/Objective Pain, stiffness and limited mobility are the main factors that lead to difficulties in performing daily activities and are also responsible for the decline in the quality of life in people with knee osteoarthritis (OA). The aim of this study was to evaluate the functional capacity and health related quality of life (HRQoL) compared to pain in patients with knee OA, as well as to determine the correlation between these three clinical variables. Methods The study involved 931 patients diagnosed with knee OA. In all patients, pain was evaluated by a short form of the McGill pain questionnaire (SF-MPQ), functional status was assessed using the Western Ontario and McMaster Universities Arthritis Index (WOMAC), while life quality was evaluated using the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36). Results The average age of patients was 61.21 ± 4.62 years, while 71.3% of them were women. The quality of life in patients with knee OA and all pain parameters contained in the SF-MPQ were highly statistically positively associated (p ≤ 0.01). In addition, the physical functioning was mostly affected by emotional pain (rho =-0.585). A high statistical correlation (p ≤ 0.01) was noted between stiffness and physical functioning from the WOMAC questionnaire and all of the parameters from the SF-MPQ. The physical functioning from the WOMAC questionnaire had the strongest correlation with total pain incorporated into the McGill questionnaire (rho = 0.530). Conclusion Knee pain has a significant impact on functional capacity and HRQoL in patients with knee OA. Therefore, one of the main therapy goals for OA of the knee should be to reduce the pain in the affected knee, which can help to improve the functionality and HRQoL of these patients.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

The impact of pain on functionality and health related quality of life in patients with knee osteoarthritis

et al. 2019

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“…To assess firstly, the safety and feasibility; and secondly, the possible benefits from hyperacute serum IA treatment in OA knees, patient reported outcomes together with synovial fluid samples were gathered. Lysholm-Tegner score, visual analog scale (VAS) and the knee injury and osteoarthritis outcome score (KOOS) are commonly used indicators for similar clinical studies in the context of OA [27][28][29][30][31]. Synovial fluid is an easily harvestable specimen that has the potential of been used as an indicator in the stage of the disease.…”

Section: Introductionmentioning

confidence: 99%

A Pilot Clinical Study of Hyperacute Serum Treatment in Osteoarthritic Knee Joint: Cytokine Changes and Clinical Effects

Calvo¹,

Fodor

Kardos

et al. 2021

CIMB

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The serum fraction of platelet-rich fibrin (hyperacute serum) has been shown to improve cartilage cell proliferation in in vitro osteoarthritic knee joint models. We hypothesize that hyperacute serum may be a potential regenerative therapeutic for osteoarthritic knees. In this study, the cytokine milieu at the synovial fluid of osteoarthritic knee joints exposed to hyperacute serum intraarticular injections was investigated. Patients with knee osteoarthritis received three injections of autologous hyperacute serum; synovial fluid was harvested before each injection and clinical monitoring was followed-up for 6 months. Forty osteoarthritic-related cytokines, growth factors and structural proteins from synovial fluid were quantified and analysed by Multivariate Factor Analysis. Hyperacute serum provided symptomatic relief regarding pain and joint stability for OA patients. Both patients “with” and “without effusion knees” had improved VAS, KOOS and Lysholm-Tegner scores 6 months after of hyperacute serum treatment. Synovial fluid analysis revealed two main clusters of proteins reacting together as a group, showing strong and significant correlations with their fluctuation patterns after hyperacute serum treatment. In conclusion, hyperacute serum has a positive effect in alleviating symptoms of osteoarthritic knees. Moreover, identified protein clusters may allow the prediction of protein expression, reducing the number of investigated proteins in future studies.

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“…The impairments and limitations associated with KOA may lead to psychosocial issues such as anxiety, depression and helplessness [10][11][12]. As a result, a decline in quality of life is reported by people with KOA [4,[13][14][15]. The impact of KOA extends beyond the individual level, as it imposes a significant burden on society and health care services [16,17].…”

Section: Introductionmentioning

confidence: 99%

The knowledge and self-management educational needs of older adults with knee osteoarthritis: A qualitative study

et al. 2020

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Knee osteoarthritis (KOA) is closely related with ageing, physical disability and functional dependency. The course of KOA is considered progressive and irreversible. Engagement with self-management may, however, minimize the impact of KOA. To be fully engaged with self-management activities, knowledge about KOA is a prerequisite. There is limited empirical data on older adults' understanding on KOA and their information needs about KOA. Therefore, the aims of this study were to explore older adults' knowledge about KOA and their perspectives on the information required to enable self-management. Three focus groups were conducted with 16 older adults with KOA. The sample consisted of three men and thirteen women with the mean age 73.2 years (range from 61 to 89). Thematic content analysis revealed two themes which were understanding about KOA and information needed about KOA. Participants' knowledge about KOA varied between individuals with many expressing that they needed more information about KOA. A targeted strategy is needed to educate older adults about KOA in order to support and prepare them for selfmanagement.

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Quality of Life in Knee Osteoarthritis; Correlation with Clinical Measures and the Knee Injury and Osteoarthritis Outcome Score

Cited by 6 publications

References 22 publications

The impact of pain on functionality and health related quality of life in patients with knee osteoarthritis

The impact of pain on functionality and health related quality of life in patients with knee osteoarthritis

A Pilot Clinical Study of Hyperacute Serum Treatment in Osteoarthritic Knee Joint: Cytokine Changes and Clinical Effects

The knowledge and self-management educational needs of older adults with knee osteoarthritis: A qualitative study

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