Phloridzin is the specific and competitive inhibition of sodium/glucose cotransporters in the intestine (SGLT1) and kidney (SGLT2). This property which could be useful in the management of postprandial hyperglycemia in diabetes and related disorders. Phloridzin is one of the dihydrochalcones typically contained in apples and in apple-derived products. The effect of phloridzin orally doses 5, 10, 20 and 40 mg/kg body weight on diabetes was tested in a streptozotocin-induced rat model of diabetes type 1. From beneficial effect of this compound is significant reduction of blood glucose levels and improve dyslipidemia in diabetic rats. As a well-known consequence of becoming diabetic, urine volume and water intake were significantly increased. Administration of phloridzin reduced urine volume and water intake in a dose-dependent manner. Phloretin decreases of food consumption, as well as a marked lowering in the weight. In conclusion, this compound could be proposed as an antihyperglycemic and antihyperlipidemic agent in diabetes and potential therapeutic in obesity.
ObjectiveCortical reorganization is one of the most plausible mechanisms underlying impairment of anticipatory postural adjustments (APAs) in low back pain (LBP) patients. In order to clarify changes in corticomotor neurophysiology, APAs were assessed by using electromyography (EMG) and electroencephalography (EEG).MethodsAn equal number (29) of nonspecific LBP patients and healthy subjects performed unilateral rapid arm movements in response to auditory imperative stimulus preceded by warning stimulus within 2 s interstimulus interval. Burst onset activity was calculated in relation to the activity of anterior deltoid for bilateral transverse abdominis/internal oblique (TrA/IO), and also postural muscles on left side, including rectus abdominis, external oblique (E.O), erector spinae and medial head of gastrocnemius (Gc.M). Contingent negative variation (CNV) potentials were recorded by scalp EEG, and the area under receiver operating characteristic curve (AUC) was analyzed.ResultsIn LBP patients, there was a significant onset delay for E.O and bilateral TrA/IO, but a significant earlier activity for Gc.M (for both P < 0.05). The CNV parameters were considerably greater in LBP patients (P < 0.01). The AUC was significant just for left TrA/IO and E.O muscles (P < 0.05).ConclusionsThe CNV amplitudes were increased, and APA onset times re-organized to be delayed at the trunk and early at the distal limb in LBP cases. These findings support the hypothesis about reorganized activity of cerebral cortex in LBP patients.
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