The solubility prediction of nabumetone was studied in different solvent system (hexane-ethyl acetate-ethanol-water). The theories such as ideal, Hildebrand-Scatchard and extended Hildebrand solubility approaches were used for finalizing the solubility behavior of nabumetone. Entropy of fusion expression was used to calculate the ideal solubility. The experimental mole fraction solubility deviated from the ideal mole fraction solubility, indicating the self association of solute or solvent or both in solution. The extended Hildebrand equation was used to reproduce solubilities of nabumetone in selected solvent blend. The solubilities of nabumetone were back calculated with an interaction energy term 'W' and rational activity coefficient term '(log10 2)/A'. These parameters were regressed against a polynomial of δ1, solubility parameter of solvent blend. Solubility parameter of the nabumetone δ2 was determined and found to be ˜ 20 MPa 1/2 .
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.