Total and partial solubility parameters prediction: Lornoxicam in individual solvents

IUPAC-NIST Solubility Data Series. 102. Solubility of Nonsteroidal Anti-inflammatory Drugs (NSAIDs) in Neat Organic Solvents and Organic Solvent Mixtures

“…The drug is prescribed in the treatment of pain resulting from osteoarthritis, sciatica, and inflammatory diseases of the joints. There have been three publications [151][152][153] reporting the solubility of lornoxicam in organic solvents. Kharwade et al 152 determined the molar solubility of lornoxicam in ethanol at 288 K. Reference 151 examined the solubility of lornoxicam in two saturated hydrocarbons (hexane and cyclohexane), in two aromatic hydrocarbons (benzene and methylbenzene), in two alkyl alkanoates (ethyl ethanoate and butyl ethanoate), in one cyclic ether (1,4-dioxane), in two chloroalkanes (trichloromethane and tetrachloromethane) and one chlorinated aromatic hydrocarbon (chlorobenzene), in nine alcohols (methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, 2-methyl-1-propanol, 1-pentanol, 1-octanol, 1,2-propanediol, and 1,2,3-propanetriol), in one alkanone (propanone) and one aromatic ketone (acetophenone), and in three miscellaneous organic solvents (dimethyl sulfoxide, N,N-dimethylformamide, and benzenamine) at 298 K and atmospheric pressure.…”

Hansen Solubility Parameters of Coal Tar-Derived Typical PAHs Using Turbidimetric Titration and an Extended Hansen Approach

“…The extended Hansen approach was thus conducted to estimate the solubility and verify the HSPs obtained from turbidimetric titration − for the six PAHs. According to the theory, the relationship between solubility and HSPs can be described as eq . where X 2 and X 2 i are the molar fraction solubility and molar fraction ideal solubility; C I , C II , C III , and C 0 are model coefficients; δ d 1 , δ p 1 , and δ hb 1 are HSPs of solute, whereas δ d 2 , δ p 2 , and δ hb 2 are HSPs of solvent; and A is a term from regular solution theory: where V 2 is molar volume of the solute, ϕ 1 is the volume fraction of solvent, R is the gas constant, and T is the absolute temperature.…”

“…Though the average value of multiple determinations (3 times, absolute deviation less than 0.03 mL) was used to reduce error, uncertainties still exist. Previous attempts made to estimate the HSPs of the six PAH compounds by an extended Hansen approach failed 24,25 due to the nonuniform distribution of test points in the 3-dimensional coordinate system. The lower part of the ellipsoidal models usually stays under the plane defined by the x-axis and y-axis, which means points in this area cannot be actually obtained from experiments.…”

Solubility data and solubility parameters of barnidipine in different pure solvents

“…The experimental mole fraction solubility data of barnidipine in seventeen mono solvents at 298.15 K and the partial parameters and total solubility parameters of solvents chosen are tabulated in Table 2. It can be seen temperature has different effects on the solubility change trend of various types of solvents (24) . Experimental mole fraction solubility was ranked in the following order: isopropyl myristate < benzene < chlorobenzene < ethyl acetate < water < 1,4-Dioxane < acetone < acetonitrile < 1,2-Dichloroethane < 1-Octanol < 1-Pentanol < ethanol < acetophenone < methanol < DEGME < acetic acid < DMF.…”