Nabumetone in Binary Solvents: Solubility Analysis

Abstract

The solubility prediction of nabumetone was studied in different solvent system (hexane-ethyl acetate-ethanol-water). The theories such as ideal, Hildebrand-Scatchard and extended Hildebrand solubility approaches were used for finalizing the solubility behavior of nabumetone. Entropy of fusion expression was used to calculate the ideal solubility. The experimental mole fraction solubility deviated from the ideal mole fraction solubility, indicating the self association of solute or solvent or both in solution. The extended Hildebrand equation was used to reproduce solubilities of nabumetone in selected solvent blend. The solubilities of nabumetone were back calculated with an interaction energy term 'W' and rational activity coefficient term '(log10 2)/A'. These parameters were regressed against a polynomial of δ1, solubility parameter of solvent blend. Solubility parameter of the nabumetone δ2 was determined and found to be ˜ 20 MPa 1/2 .

Solubility of anti-inflammatory drug lornoxicam in ten different green solvents at different temperatures

“…Moreover, the solubility of LOX in various pure solvents such as water, ethanol, ethyl acetate (EA), PG and PEG-400 at 298.15 K has also been reported in literature [3]. However, the temperature dependent solubility data of LOX in water, ethanol, ethylene glycol (EG), EA, 1-butanol, 2-butanol, isopropyl alcohol (IPA), PG, PEG-400 and 2-(2-ethoxyethoxy) ethanol are not available in literature.…”

“…It is commercially available as orange to yellow crystalline powder [2]. It is a newly launched non-steroidal anti-inflammatory drug (NSAID) which is used in the treatment of pains associated with rheumatoid arthritis, osteoarthritis, ankylosing spondylitis and postoperative dental pain [3][4][5]. It is marketed in the form of tablets and injections and its dose is relatively low as compared to other NSAIDs [3].…”

“…It is a newly launched non-steroidal anti-inflammatory drug (NSAID) which is used in the treatment of pains associated with rheumatoid arthritis, osteoarthritis, ankylosing spondylitis and postoperative dental pain [3][4][5]. It is marketed in the form of tablets and injections and its dose is relatively low as compared to other NSAIDs [3]. It has been reported as practically insoluble in water which results in poor in vivo absorption and bioavailability upon oral administration [1,3].…”

“…It is marketed in the form of tablets and injections and its dose is relatively low as compared to other NSAIDs [3]. It has been reported as practically insoluble in water which results in poor in vivo absorption and bioavailability upon oral administration [1,3]. The solubility data of solid solutes in pure solvents could be useful in purification, crystallization, drug development process and formulation development [6][7][8].…”

“…Recently, 2-(2-ethoxyethoxy) ethanol (Transcutol) has also been investigated as a potential green solvent for solubility enhancement of various poorly water soluble drugs [11,12]. Various approaches such as cosolvency, solid dispersion and complexation have been investigated for solubility and dissolution enhancement of LOX in literature [3,[13][14][15].…”